Cizutamig
Based on 1 Customer Validation
Cizutamig (CND-106) is a bispecific T-cell engager targeting BCMA and CD3. Cizutamig exhibits immunostimulatory and anti-tumor activities. Cizutamig can be used in research related to relapsed or refractory multiple myeloma and systemic lupus erythematosus.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 95%
- CAS 番号: 2919209-65-5
- 分子量:241.429 kDa
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
生物活性
[L-kappa-H-gamma1_[VH-G1(CH1-h)]_Lkappa] dimer
Human
TNFRSF17 & CD3E
Cizutamig exhibits binding affinity to BCMA-expressing myeloma cell lines comparable to that of T cell engagers (TCEs), while its binding affinity to CD3-positive Jurkat T cells is lower than that of the benchmark BCMA×CD3 TCE[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Cynomolgus monkeys[1]
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Dosage:0.5 mg/kg
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Administration:i.v.; single dose
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Result:Caused transient decrease in peripheral blood T cells indicative of margination.
Sustained reductions in circulating B cells.
Induced limited, transient cytokines.
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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VK-CK-VH-CH1-h-CH2-CH3_L-kappa_Fab-G1-kappa
ELISA, FACS, Functional assay
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Loaded Cizutamig on ProA biosensor, can bind BCMA/TNFRSF17 Protein, Human (Biotinylated, HEK293, His-Avi, HY-P78070) with an affinity constant of 8.191E-11 M as determined in BLI assay.
化学情報
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CAS 番号 2919209-65-5
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性状 Liquid
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分子量 241.429 kDa
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Color Colorless to light yellow
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SMILES
[Cizutamig]
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別名
CND-106; EMB-06
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輸送条件
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
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データシート (259 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)