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製品番号: HY-189048

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CPN4F

CPN4F is a chalcone derivative with antiparasitic activity. CPN4F is an inhibitor of the cysteine protease cruzain. CPN4F forms a key hydrogen bond with the Trp-184 residue in the active site of parasitic cruzain as an electrophile, and induces oxidative stress, cell membrane degradation, and necrosis, thereby inhibiting parasite proliferation. CPN4F is used in research related to Chagas disease.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₁₈H₁₇FO₅
分子量:332.32

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

CPN4F 構造式

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

IC₅₀ & Target

^[1]

Trypanosoma

cathepsin L

Parasite アイソフォーム固有の製品をすべて表示 :

Cathepsin アイソフォーム固有の製品をすべて表示 :

体外実験

Parasitic InfectionOthers

Parasitic Infection

CPN4F (15.6-1000 μM; 24-72 h) exerts potent antiproliferative effects on epimastigotes of T. cruzi strain Y, with IC₅₀ values of 356.70 μM, 149.30 μM, and 22.95 μM at 24 h, 48 h, and 72 h, respectively^[1].
CPN4F (31.2-1000 μM; 24 h) exhibits excellent trypanocidal activity against trypomastigotes of T. cruzi strain Y, with an LC₅₀ of 32.54 μM^[1].

Others

CPN4F (15.6-1000 μM; 24 h) exhibits significant cytotoxicity in LLC-MK2 host cells, causing a concentration-dependent decrease in cell viability, with a CC₅₀ of 99.26 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

LLC-MK2 cells
Concentration:

15.6, 31.2, 62.5, 125, 250, 500, 1000 μM
Incubation Time:

24 h
Result:

Exhibited significant host cell toxicity.

Cell Viability Assay^[1]

Cell Line:

Epimastigote forms of T. cruzi strain Y
Concentration:

15.6, 31.2, 62.5, 125, 250, 500, 1000 μM
Incubation Time:

24 h, 48 h, 72 h
Result:

Demonstrated time- and concentration-dependent antiproliferative effects on epimastigotes.

Cell Viability Assay^[1]

Cell Line:

Trypomastigote forms of T. cruzi strain Y
Concentration:

31.2, 62.5, 125, 250, 500, 1000 μM
Incubation Time:

24 h
Result:

Effectively killed the trypomastigotes with LC₅₀ of 32.54 μM.

Related Protocols :

化学情報

分子量 332.32
分子式 C₁₈H₁₇FO₅
SMILES

O=C(C1=C(OC)C=C(OC)C(OC)=C1O)/C=C/C2=CC=C(F)C=C2
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Pinto Filho JIL, et al. Evaluation of Chalcone ()‑3-(4-Fluorophenyl)-1-(2-hydroxy-3,4,6-trimethoxyphenyl)-prop-2-en-1-one against (Y Strain): In Vitro Assay, In Silico Drug-Target Analysis, and MPO-Based Drug Likeness. ACS omega. 2026 Aug 04;11(30):44583-44613.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Other size

お問い合わせ

Amount: USD 0.00

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
化学情報
純度とドキュメンテーション
参考文献

製品名:
製品番号:
数量:
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CPN4F

Parasite アイソフォーム固有の製品をすべて表示

Cathepsin アイソフォーム固有の製品をすべて表示

生物活性

製品説明

IC50 & Target

体外実験

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

CPN4F 関連分類

HY-189048 関連分類

Bioz

Keywords

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