Crobenetine
Crobenetine (BIII-890), a benzomorphan derivative, is a potent, selective, and highly use-dependent Na+ channel blocker. Crobenetine displaces [3H]BTX from site 2 of the Na+ channel (IC50=49 nM) in rat brain synaptosomes, yet exhibits only low binding affinity for other receptors and ion channels. Crobenetine protects brain tissue from the deleterious effects of focal cerebral ischemia in rodents.
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- CAS 番号: 221019-25-6
- 分子式: C25H33NO2
- 分子量:379.54
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 221019-25-6
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分子量 379.54
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分子式 C25H33NO2
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SMILES
OC1=C2C([C@]3(C)CCN(C[C@@H](OCC4=CC=CC=C4)C)[C@](C3(C)C)([H])C2)=CC=C1
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別名
BIII-890; BIII-890 CL free acid
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Crobenetine 関連分類
HY-16923 関連分類
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