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製品番号: HY-128562

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CS-1-69

CS-1-69 is an MBD2 ligand analog that does not bind to individual NuRD components MBD2 or HDAC1, but binds robustly to the assembled NuRD complex (MBD2, HDAC1, and MT1A) in a dose-responsive manner. CS-1-69 attenuates Transcriptional Repression via Active Chemical Epigenetic Reprogrammin (TRACER)-mediated strogen receptor (ER) inhibitory activity.

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CAS 番号: 315702-79-5
分子式: C₁₄H₁₁N₃OS
分子量:269.32

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Please store the product under the recommended conditions in the Certificate of Analysis.

CS-1-69 構造式

CAS 番号: 315702-79-5

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Estrogen Receptor/ERR アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	EC₅₀	<1.2 μM Compound: 21	Inhibition of VCP in human HeLa cells assessed as stabilization of ubiquitin-tagged luciferase after 24 hrs by reporter gene assay Inhibition of VCP in human HeLa cells assessed as stabilization of ubiquitin-tagged luciferase after 24 hrs by reporter gene assay	[PMID: 20137940]
RCC4	GI₅₀	36 μM Compound: 79	Growth inhibition of VHL-null human RCC4 cells after 4 days by XTT assay Growth inhibition of VHL-null human RCC4 cells after 4 days by XTT assay	[PMID: 19994864]

体外実験

CS-1-69 (0-150 μM; 1 h) binds specifically to the assembled NuRD complex of purified MBD2, HDAC1, and MT1A proteins in a dose-responsive manner, with no binding to isolated MBD2 or HDAC1^[1].
CS-1-69 (25 μM; 24 h) blocks CS-1-103-mediated inhibition of ER transcriptional activity in T47D breast cancer cells, confirming CS-1-103 acts via recruitment of MBD2^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 315702-79-5
分子量 269.32
分子式 C₁₄H₁₁N₃OS
SMILES

OC1=CC=C(NC2=NC(C3=NC=CC=C3)=CS2)C=C1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Stieger CE, et al. Targeted Transcriptional Repression by Induced Proximity. bioRxiv [Preprint]. 2025 Oct 22:2025.10.22.680877.
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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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CS-1-69

Estrogen Receptor/ERR アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

CS-1-69 関連分類

HY-128562 関連分類