Derquantel
Based on 1 Customer Validation
Derquantel, a spirocyclic anthelmintic, is a competitive, orally active nicotinic acetylcholine receptor (nAChR) antagonist. Derquantel inhibits ACh-induced depolarization with an IC50 of 0.22 μM. By selectively antagonizing nAChRs on the somatic muscles of nematodes, Derquantel causes flaccid paralysis of muscles, thereby dislodging parasites from the host's gastrointestinal tract. Derquantel is applicable to research related to Haemonchus contortus infection and Ascaris suum infection.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.4%
- CAS 番号: 187865-22-1
- 分子式: C28H37N3O4
- 分子量:479.61
-
保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
-
HY-107670
Dihydro-β-erythroidine hydrobromide
-
HY-W001909
Myosmine
-
HY-105670
PHA-543613
-
HY-129674
PHA 568487 free base
-
HY-101347
Chlorisondamine diiodide
-
HY-107678
SEN12333
-
HY-134220
Doramectin monosaccharide
-
HY-135483A
AR-R17779 hydrochloride
-
HY-59201A
A-582941 dihydrochloride
-
HY-107682
TQS
-
HY-107672
MG624
-
HY-B0767
Spinosyn A
Parasite アイソフォーム固有の製品をすべて表示
More
生物活性
Derquantel (1 μM) acts as a competitive antagonist of acetylcholine-induced contractions in Ascaris suum somatic muscle strips, shifting the acetylcholine EC50 from 7 μM to 52 μM[2].
Derquantel (0.1-30 μM; 0-4 min) potently and reversibly inhibits acetylcholine-induced depolarizations in Ascaris suum somatic muscle flap preparations with an IC50 of 200 nM, acting as a competitive antagonist[2].
Derquantel (1 μM; 30 min pre-incubation) shifts the acetylcholine EC50 from 4.5 μM to 10.2 μM and reduces the maximum depolarization response in Ascaris suum somatic muscle flap preparations, consistent with competitive antagonism[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
-
CAS 番号 187865-22-1
-
性状 Solid
-
分子量 479.61
-
分子式 C28H37N3O4
-
Color White to off-white
-
SMILES
CN([C@]12[C@](C[C@@]34N(CC[C@]3(O)C)C2)([H])C(C)([C@@]5(C6=CC=C(OC(C)(C=CO7)C)C7=C6NC5)C1)C)C4=O
-
別名
PF-00520904
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
純度とドキュメンテーション
-
データシート (273 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
取扱説明書 (2659 KB)
参考文献
[1]. Sager H, et al. Efficacy of monepantel, derquantel and abamectin against adult stages of a multi-resistant Haemonchus contortus isolate. Parasitol Res. 2012;111(5):2205-2207. [Content Brief]
[2]. Puttachary S, et al. Derquantel and abamectin: effects and interactions on isolated tissues of Ascaris suum. Mol Biochem Parasitol. 2013;188(2):79-86. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Derquantel 関連分類
HY-125159 関連分類
Powered by Bioz
- Derquantel
- 187865-22-1
- PF-00520904
- PF00520904
- PF 00520904
- Parasite
- nAChR
- acetylcholine
- GABA
- nematode species
- somatic muscle nicotinic acetylcholine receptor
- Ascaris suum
- multi-resistant Haemonchus contortus isolates
- Haemonchus contortus
- sheep
- abamectin
- pharyngeal glutamate-gated chloride receptors
- Inhibitor
- inhibitor
- inhibit