DQ 2556
DQ 2556 is a semi-synthetic cephalosporin antibiotic. DQ-2556 exhibits significant activity against both Gram-positive and Gram-negative bacteria, particularly Gram-positive bacteria and Enterobacteriaceae infections. DQ 2556 exerts its bactericidal effect by interfering with cell division. DQ-2556 has a strong affinity for the penicillin-binding proteins (PBPs) of Escherichia coli: PBP1A/1B (IC₅₀ = 0.57-0.73 μg/mL) and PBP3 (IC₅₀ = 0.088 μg/mL). DQ-2556 demonstrates significant in vivo protective effects. DQ-2556 can be used in the development of injectable cephalosporins.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 102253-70-3
- 分子式: C22H19N7O6S2
- 分子量:541.56
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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生物活性
製品説明
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β-lactam |
体外実験
DQ-2556 is active against Gram-positive bacteria, sensitive to methicillin-resistant Staphylococcus (MIC90 = 1.56-3.13 μg/mL), highly active against Streptococcus (MIC90 ≤ 0.05 μg/mL), and has limited activity against Enterococcus (MIC90 = 50 μg/mL)[1][2].
DQ-2556 is active against Gram-negative bacteria, has an MIC₉₀ value of no more than 0.05 μg/mL against Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis, etc. and sensitive to Haemophilus influenzae and Neisseria gonorrhoeae with MIC90 of 0.1 μg/mL[1][2].
DQ-2556 has the same or ≤ 4-fold MIC₉₀ value against Staphylococcus aureus, Escherichia coli, and Proteus mirabilis[1][2].
DQ-2556 (0.0008-12.5 μg, 4 h) induces the formation of filamentous and spherical structures in Escherichia coli, and also induced cell lysis at higher concentrations[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 102253-70-3
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分子量 541.56
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分子式 C22H19N7O6S2
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SMILES
[O-]C(C1=C(C[N+]2=CC=C(C3=CN=CO3)C=C2)CS[C@@]([C@@H]4NC(/C(C5=CSC(N)=N5)=N\OC)=O)([H])N1C4=O)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
DQ 2556 関連分類
HY-106095 関連分類
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