DYRKtide
Based on 1 Customer Validation
DYRKtide is a peptide substrate for DYRK family kinases and can be used to measure DYRK1A substrate phosphorylation and the catalytic activity of DYRK1A mutants. DYRKtide can be used in studies related to in vitro kinase activity assays and in research on DYRK1A-related diseases.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.57%
- CAS 番号: 2250228-51-2
- 分子式: C79H135N31O17
- 分子量:1791.11
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保管条件:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
DYRK1A |
DYRK1B |
DYRK2 |
DYRK4 |
体外実験
DYRKtide is phosphorylated by recombinant DYRK1A, DYRK1B, MNB, DYRK2, and DYRK4, and Harmine (HY-N0737A) inhibits mature DYRK1A-mediated DYRKtide phosphorylation with an IC50 of 0.033 μM[2].
DYRKtide serves as a phospho-acceptor substrate for determining DYRKs activity in cell-free DYRKs kinase assays[3].
DYRKtide is phosphorylated by wild-type DYRK1A[4].
DYRKtide is a substrate peptide in the cell-free DYRK1A Cook assay, and its DYRK1A-mediated phosphorylation can be inhibited by the tested small molecules, with Ki values below 5 µM[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 2250228-51-2
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性状 Solid
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分子量 1791.11
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分子式 C79H135N31O17
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Color White to off-white
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配列
Arg-Arg-Arg-Phe-Arg-Pro-Ala-Ser-Pro-Leu-Arg-Gly-Pro-Pro-Lys
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シーケンスの短縮
RRRFRPASPLRGPPK
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
体外:
DMSO : 100 mg/mL (55.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.5583 mL | 2.7916 mL | 5.5831 mL | 13.9578 mL |
| 5 mM | 0.1117 mL | 0.5583 mL | 1.1166 mL | 2.7916 mL | |
| 10 mM | 0.0558 mL | 0.2792 mL | 0.5583 mL | 1.3958 mL | |
| 15 mM | 0.0372 mL | 0.1861 mL | 0.3722 mL | 0.9305 mL | |
| 20 mM | 0.0279 mL | 0.1396 mL | 0.2792 mL | 0.6979 mL | |
| 25 mM | 0.0223 mL | 0.1117 mL | 0.2233 mL | 0.5583 mL | |
| 30 mM | 0.0186 mL | 0.0931 mL | 0.1861 mL | 0.4653 mL | |
| 40 mM | 0.0140 mL | 0.0698 mL | 0.1396 mL | 0.3489 mL | |
| 50 mM | 0.0112 mL | 0.0558 mL | 0.1117 mL | 0.2792 mL |
DYRKtide 関連分類
HY-P5430 関連分類
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