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製品番号: HY-163483

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ELQ-598

ELQ-598, as a prodrug, is converted into the active drug ELQ-596 upon oral administration. ELQ-598 demonstrates potent parasitic growth inhibition capabilities (IC₅₀= 37 nM). ELQ-598 also shows low toxicity towards human cells (IC₅₀= 19 μM). ELQ-598 can be used for research into babesiosis.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 3023709-99-8
分子式: C₂₈H₂₃ClF₃NO₆
分子量:561.93

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (282 KB)

ELQ-598 構造式

CAS 番号: 3023709-99-8

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Parasite アイソフォーム固有の製品をすべて表示 :

体内実験

ELQ-598 (10 mg/kg; p.o.; daily DPI 3-7) achieves complete elimination of B. duncani infection in C3H mice^[1].
ELQ-598 (10 mg/kg; p.o.; daily DPI 3-7) is effective at eliminating B. microti infection in mice^[1].
ELQ-598 (10 mg/kg; p.o.; daily DPI 3-7) combined with atovaquone (HY-13832) can eliminative of the infection in the C3H/HeJ mice infected with B. duncani and SCID mice model infected with B. microti^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C3H mice genetically prone to B. duncani infection^[1]
Dosage:

10mg/kg
Administration:

p.o.; daily DPI 3-7
Result:

Resulted in a complete elimination of the parasites. Mice survived for the duration of the study with no recurrence of parasitemia observed.

Animal Model:

C3H/HeJ mice for B. duncani infection, and SCID mice for B. microti infection^[1]
Dosage:

10mg/kg with 10mg/kg atovaquone,
Administration:

p.o.; daily DPI 3-7
Result:

All mice survived without any recurrence of parasitemia.
A potent synergistic or additive effect of the drug combination in eradicating the lethal infection.This combination strategy offers enhanced efficacy compared to the use of either compound alone.

Related Protocols :

How to Select the Route of Administration for Mammals

化学情報

CAS 番号 3023709-99-8
分子量 561.93
分子式 C₂₈H₂₃ClF₃NO₆
SMILES

ClC1=CC2=C(N=C(C)C(C3=CC=C(C4=CC=C(OC(F)(F)F)C=C4)C=C3)=C2OCOC(OCC)=O)C=C1OC
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (282 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Vydyam P, et al. Effectiveness of Two New Endochin-like Quinolones, ELQ-596 and ELQ-650, in Experimental Mouse Models of Human Babesiosis. ACS Infect Dis. 2024 Apr 12;10(4):1405-1413. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Minimum order quantity

100 mg

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