EMD 53998
Based on 1 Customer Validation
EMD 53998 is a cardiotonic agent that increases myocardial contractility as an inhibitor for phosphodiesterase III (PDE III) and a calcium sensitizer. EMD 53998 increases myocardial contractility, reduces energy consumption and the risk of inducing arrhythmias.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.59%
- CAS 番号: 120223-04-3
- 分子式: C22H23N3O4S
- 分子量:425.50
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
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PDE3 |
体外実験
EMD 53998, a racemic thiadiazinone derivative, is a potent Ca2+-sensitizer. EMD 53998 (0.1-100 μM) increases force of contraction (FOC) in a concentration-dependent manner. EMD 53998 increases force of contraction in human myocardium via sensitizing of the contractile proteins towards Ca2+ and by inhibition of phosphodiesterase III-isoenzymes[12].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
化学情報
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CAS 番号 120223-04-3
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性状 Solid
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分子量 425.50
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分子式 C22H23N3O4S
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Color White to off-white
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SMILES
O=C(C1=CC(OC)=C(OC)C=C1)N2C3=CC=C(C(C(S4)C)=NNC4=O)C=C3CCC2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
体外:
DMSO : 100 mg/mL (235.02 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Lues I, et al., The two mechanisms of action of racemic cardiotonic EMD 53998, calcium sensitization and phosphodiesterase inhibition, reside in different enantiomers. J Cardiovasc Pharmacol. 1993 Jun;21(6):883-92. [Content Brief]
[2]. Uhlmann R, et al. EMD 53998 acts as Ca(2+)-sensitizer and phosphodiesterase III-inhibitor in human myocardium. Basic Res Cardiol. 1995 Sep-Oct;90(5):365-71. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3502 mL | 11.7509 mL | 23.5018 mL | 58.7544 mL |
| 5 mM | 0.4700 mL | 2.3502 mL | 4.7004 mL | 11.7509 mL | |
| 10 mM | 0.2350 mL | 1.1751 mL | 2.3502 mL | 5.8754 mL | |
| 15 mM | 0.1567 mL | 0.7834 mL | 1.5668 mL | 3.9170 mL | |
| 20 mM | 0.1175 mL | 0.5875 mL | 1.1751 mL | 2.9377 mL | |
| 25 mM | 0.0940 mL | 0.4700 mL | 0.9401 mL | 2.3502 mL | |
| 30 mM | 0.0783 mL | 0.3917 mL | 0.7834 mL | 1.9585 mL | |
| 40 mM | 0.0588 mL | 0.2938 mL | 0.5875 mL | 1.4689 mL | |
| 50 mM | 0.0470 mL | 0.2350 mL | 0.4700 mL | 1.1751 mL | |
| 60 mM | 0.0392 mL | 0.1958 mL | 0.3917 mL | 0.9792 mL | |
| 80 mM | 0.0294 mL | 0.1469 mL | 0.2938 mL | 0.7344 mL | |
| 100 mM | 0.0235 mL | 0.1175 mL | 0.2350 mL | 0.5875 mL |
EMD 53998 関連分類
HY-106844 関連分類
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