ent-Estradiol
Ent-Estradiol is the enantiomer of Estradiol (HY-B0141). Ent-Estradiol is a highly selective estrogen receptor ligand, but does not possess estrogenic activity. Ent-Estradiol displays IC50 values of 24.9 nM, 9.59 nM and 8.17 nM for human, rat and mouse ERβ, and 151 nM, 246 nM and 268 nM for human, rat and mouse ERα, respectively. Ent-Estradiol can be used for the study of menopausal physiological changes.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 3736-22-9
- 分子式: C18H24O2
- 分子量:272.38
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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hERα 151 nM (IC50) |
mouse ERα 268 nM (IC50) |
rat ERα 246 nM (IC50) |
hERβ 24.9 nM (IC50) |
rat ERβ 9.59 nM (IC50) |
mouse ERβ 8.17 nM (IC50) |
Ent-Estradiol (eight dilutions; 5-18 h) selectively binds to ER-β over ER-α across human, rat, and mouse receptors, with the highest selectivity observed for mouse ER-β, and exhibits IC50 values of 24.9 nM (human ER-β), 9.59 nM (rat ER-β), 8.17 nM (mouse ER-β), 151 nM (human ER-α), 246 nM (rat ER-α), and 268 nM (mouse ER-α)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 3736-22-9
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分子量 272.38
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分子式 C18H24O2
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SMILES
C[C@]12[C@@](CC[C@H]2O)([H])[C@]3([H])[C@](CC1)([H])C4=CC=C(O)C=C4CC3
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別名
ent-β-Estradiol; ent-17β-Estradiol; ent-17β-Oestradiol
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
ent-Estradiol 関連分類
HY-B0141E 関連分類
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