Fulipiftide
Based on 1 Customer Validation
Fulipiftide (PSP 29-mer) is a short peptide derived from pigment epithelium-derived factor (PEDF). Fulipiftide induces the phosphorylation of ERK2 and STAT3, enriches tendon stem/progenitor cell markers, maintains cell stemness, promotes colony formation and niche expansion, and drives cell infiltration into injured tendons. Fulipiftide promotes the oriented formation of collagen fibers, regulates collagen deposition, and reduces inflammatory cell infiltration and neovascularization. Fulipiftide can be used in studies related to acute tendon injury.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.38%
- CAS 番号: 2868985-56-0
- 分子式: C144H227N41O47
- 分子量:3284.59
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保管条件:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
ERK2 |
STAT3 |
体外実験
Fulipiftide (PSP 29-mer) (10 μM) induces proliferation of nucleostemin-positive tendon stem/progenitor cells from primary rabbit tendon cells via activation of ERK2 and STAT3 signaling pathways[1].
Fulipiftide (10 μM; 10 days) expands tendon stem/progenitor cells (TSPC) from primary rabbit tendon cells by increasing clonogenic capacity and enriching expression of TSPC markers CD146, Oct4, and nestin[1].
Fulipiftide (10 μM; 10 days) expanded tendon stem/progenitor cells from primary rabbit tendon cells retain the capacity for tenogenic differentiation, as shown by increased expression of tenocyte lineage-related genes after peptide withdrawal[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley (male, 10 weeks old, initial body weight 312 g)[1]
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Dosage:100 μM
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Administration:subcutaneous injection; single dose
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Result:Increased CD146+ TSPC count to 61.4 per microscope field in the peripheral tendon region at 2 days post-surgery.
Increased BrdU co-labeling rate of CD146+ TSPC to 32.4% at 2 days post-surgery.
Increased CD146+ TSPC count to 59.6 per microscope field in the healing region at 7 days post-surgery.
Increased BrdU co-labeling rate of nucleostemin+ TSPC to 15.8% at 7 days post-surgery.
Achieved 89.1% of the ultimate tensile stress and 89.3% of the Young’s modulus of contralateral intact tendons at 3 weeks post-surgery.
Reduced histological scores for fiber arrangement, fiber structure, nuclear roundness, inflammatory cell/fibroblast infiltration, and neoangiogenesis compared to vehicle controls at 3 weeks post-surgery.
Induced densely aligned collagen fibers, reduced inflammatory cell invasion, fewer neovessels, stronger type I collagen expression, and type III collagen expression similar to intact tendons at 3 weeks post-surgery.
化学情報
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CAS 番号 2868985-56-0
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性状 Solid
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分子量 3284.59
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分子式 C144H227N41O47
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Color White to off-white
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別名
PSP 29-mer, anti-inflammatory peptide
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配列
Ac-Ser-Leu-Gly-Ala-Glu-Gln-Arg-Thr-Glu-Ser-Ile-Ile-His-Arg-Ala-Leu-Tyr-Tyr-Asp-Leu-Ile-Ser-Ser-Pro-Asp-Ile-His-Gly-Thr-NH2
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シーケンスの短縮
Ac-SLGAEQRTESIIHRALYYDLISSPDIHGT-NH2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
体外:
DMSO : 50 mg/mL (15.22 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (291 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
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- Italian - IT (252 KB)
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- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.3045 mL | 1.5223 mL | 3.0445 mL | 7.6113 mL |
| 5 mM | 0.0609 mL | 0.3045 mL | 0.6089 mL | 1.5223 mL | |
| 10 mM | 0.0304 mL | 0.1522 mL | 0.3045 mL | 0.7611 mL | |
| 15 mM | 0.0203 mL | 0.1015 mL | 0.2030 mL | 0.5074 mL |
Fulipiftide 関連分類
HY-P10953 関連分類
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