ABL2 - ABL proto-oncogene 2, non-receptor tyrosine kinase Gene

Also Known as ARG; ABLL

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 27

About ABL2

Cytogenetic location: 1q25.2 Genomic coordinates (GRCh38): 1:179,099,330-179,229,677 (from NCBI)

This gene has 14 transcripts (splice variants), 210 orthologues, 32 paralogues and is associated with 85 phenotypes. Ubiquitous expression in gall bladder (RPKM 5.8), appendix (RPKM 2.3) and 25 other tissues.

Summary

This gene encodes a member of the Abelson family of nonreceptor tyrosine protein kinases. The protein is highly similar to the c-abl oncogene 1 protein, including the tyrosine kinase, SH2 and SH3 domains, and it plays a role in cytoskeletal rearrangements through its C-terminal F-actin- and microtubule-binding sequences. This gene is expressed in both normal and tumor cells, and is involved in translocation with the ets variant 6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2009]

ABL2 Products (8)

mRNA	Protein	Name
NM_001136000.3	NP_001129472.1	tyrosine-protein kinase ABL2 isoform d
NM_001136001.2	NP_001129473.1	tyrosine-protein kinase ABL2 isoform e
NM_001168236.2	NP_001161708.1	tyrosine-protein kinase ABL2 isoform f
NM_001168237.2	NP_001161709.1	tyrosine-protein kinase ABL2 isoform g
NM_001168238.2	NP_001161710.1	tyrosine-protein kinase ABL2 isoform h
NM_001168239.2	NP_001161711.1	tyrosine-protein kinase ABL2 isoform i
NM_005158.5	NP_005149.4	tyrosine-protein kinase ABL2 isoform c
NM_007314.4	NP_009298.1	tyrosine-protein kinase ABL2 isoform b

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	参考文献	由来
enables magnesium ion binding	IDA IDA: Inferred from direct assay	15886098	GOA
enables manganese ion binding	IDA IDA: Inferred from direct assay	15886098	GOA
enables phosphotyrosine residue binding	IPI IPI: Inferred from physical interaction	20624904	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12893824	GOA
enables protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	15886098	GOA
enables protein tyrosine kinase activity	IMP IMP: Inferred from mutant phenotype	22810897	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in cellular response to retinoic acid	IMP IMP: Inferred from mutant phenotype	17910947	GOA
involved in peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	15886098	GOA
acts upstream of or within phospholipase C-activating G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	24367707	GOA
acts upstream of or within positive regulation of cytosolic calcium ion concentration	IMP IMP: Inferred from mutant phenotype	24367707	GOA
involved in positive regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	17910947	GOA
involved in positive regulation of oxidoreductase activity	IDA IDA: Inferred from direct assay	12893824	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ABL2 Protein Structure

SH3_1

SH2

Pkinase_Tyr

F_actin_bind

0
200
400
600
800
1000
1182 a.a.

Protein Preferred Names	Protein Names
tyrosine-protein kinase ABL2	Abelson tyrosine-protein kinase 2

ABL2 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	ABL2	P42684	KIT	Homo sapiens	P10721	FPS	24728074
Intra	ABL2	P42684	EGFR	Homo sapiens	P00533	Protein Array	16273093
Intra	ABL2	P42684	RIN1	Homo sapiens	Q13671	Anti Tag CoIP	15886098
Intra	ABL2	P42684	NCK1	Homo sapiens	P16333	Peptide Array	17474147
Intra	ABL2	P42684	GRB2	Homo sapiens	P62993	Peptide Array	17474147
Intra	ABL2	P42684	SRC	Homo sapiens	P12931	Peptide Array	17474147
Intra	ABL2	P42684	ERBB2	Homo sapiens	P04626	Protein Array	16273093
Intra	ABL2	P42684	ERBB3	Homo sapiens	P21860	Protein Array	16273093
Intra	ABL2	P42684	SF1	Homo sapiens	Q15637	Y2H Fragment Pooling	26420826
Intra	ABL2	P42684	PLCG1	Homo sapiens	P19174	Pull Down	17474147
Intra	ABL2	P42684	PLCG1	Homo sapiens	P19174	Peptide Array	17474147
Intra	ABL2	P42684	PIK3R1	Homo sapiens	P27986	Peptide Array	17474147
Intra	ABL2	P42684	ERBB4	Homo sapiens	Q15303	Protein Array	16273093
Intra	ABL2	P42684	CRK	Homo sapiens	P46108	Peptide Array	17474147

Cross: Cross-species interaction Intra: Intraspecies interaction

ABL2 抗体

製品番号	製品名	アプリケーション	反応性
HY-P83458	ABL2 Antibody (YA3203)	WB, FC	Human, Mouse, Rat
HY-P83458A	ABL2 Antibody (YA3203)(PBS only)	WB, FC	Human, Mouse, Rat
HY-P85044	ABL2 Antibody (YA4736)	ICC/IF, ELISA	Human, Mouse
HY-P85044A	ABL2 Antibody (YA4736)(PBS only)	ICC/IF, ELISA	Human, Mouse

Diseases	Alias
Leukemia	Leukemias Leukaemia, Unspecified, Without Mention Of Remission Aleukemic Leukaemia Chronic Leukaemia Subacute Leukaemia Leukaemia Disorder Leukaemia Nos
B-Lymphoblastic Leukemia/Lymphoma With Bcr-Abl1	B-All With Bcr-Abl1 B-Lymphoblastic Leukemia/Lymphoma With T(9 22)(Q34.1 Q11.2) Bcr-Abl1 B Lymphoblastic Leukemia/Lymphoma With T(9 22)(Q34.1 Q11.2) Bcr-Abl1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

製品番号	製品名	製品効果	純度	Phase
HY-148794	Risvodetinib	Inhibitor	99.21%	Phase 2

Pre-clinical Phase

Bioactive Molecules (10)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-148061	DB1113		99.86%	Unkown
HY-148063	DB0614		99.92%	Unkown
HY-148066	DB0662	Degrader	99.66%	Unkown
HY-178382	BRAFV600E/ABL2-IN-1		/	Unkown
HY-181726	BRAFV600E/ABL2-IN-2		/	Unkown
HY-182792	Embibatinib	Inhibitor	/	Unkown
HY-184274	EGFR/c-SRC-IN-1		/	Unkown
HY-RS00105	ABL2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18744	Abl2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25231	Abl2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Macaca mulatta	ABL2	VGNC	VGNC:69586
Rattus norvegicus	ABL2	RGD	RGD:1590898
Bos taurus	ABL2	VGNC	VGNC:50227
Mus musculus	ABL2	MGD	MGI:87860
Canis familiaris	ABL2	VGNC	VGNC:53323
Felis catus	ABL2	VGNC	VGNC:68440
Others	ABL2	NCBI