CASP3 - caspase 3 Gene
Also Known as CPP32; SCA-1; CPP32B
生物種: Homo sapiens
About CASP3
This gene has 11 transcripts (splice variants), 339 orthologues, 16 paralogues and is associated with 40 phenotypes. Ubiquitous expression in duodenum (RPKM 26.8), small intestine (RPKM 21.6) and 25 other tissues.
Summary
The protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell Apoptosis. The encoded protein cleaves and inactivates poly(ADP-ribose) polymerase while it cleaves and activates sterol regulatory element binding proteins as well as caspases 6, 7, and 9. This protein itself is processed by caspases 8, 9, and 10. It is the predominant Caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. [provided by RefSeq, Aug 2017]
CASP3 Products (13)
| mRNA | Protein | Name |
|---|---|---|
| NM_032991.3 | NP_116786.1 | caspase-3 isoform a preproprotein |
| NM_001354784.2 | NP_001341713.1 | caspase-3 isoform e |
| NM_001354777.2 | NP_001341706.1 | caspase-3 isoform a preproprotein |
| XM_047416238.1 | XP_047272194.1 | caspase-3 isoform X1 |
| NM_001354780.2 | NP_001341709.1 | caspase-3 isoform b |
| XM_047416236.1 | XP_047272192.1 | caspase-3 isoform X1 |
| NM_001354782.2 | NP_001341711.1 | caspase-3 isoform c |
| NM_001354781.2 | NP_001341710.1 | caspase-3 isoform c |
| XM_047416237.1 | XP_047272193.1 | caspase-3 isoform X1 |
| NM_001354783.2 | NP_001341712.1 | caspase-3 isoform d |
| NM_001354779.2 | NP_001341708.1 | caspase-3 isoform b |
| XM_047416239.1 | XP_047272195.1 | caspase-3 isoform X1 |
| NM_004346.4 | NP_004337.2 | caspase-3 isoform a preproprotein |
| Cellular Component GO Annotation | Evidence | 参考文献 | 由来 |
|---|---|---|---|
| is active in cytoplasm |
IDA
IDA: Inferred from direct assay
|
17167422 | GOA |
| located in cytosol |
IDA
IDA: Inferred from direct assay
|
17167422 | GOA |
| is active in nucleus |
IDA
IDA: Inferred from direct assay
|
16374543 | GOA |
| located in nucleus |
IDA
IDA: Inferred from direct assay
|
17167422 | GOA |
CASP3 Protein Structure
Peptidase_C14: Caspase domain (45 - 275)
- 0
- 100
- 200
- 277 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
caspase-3 |
|
|
CASP3 Protein-protein interaction Information
|
Type
|
タンパク質名 | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | 参考文献 |
|---|---|---|---|---|---|---|---|
|
Intra
|
CASP3 | P42574 | WNK3 | Homo sapiens | Q9BYP7 | 16501604 | |
|
Intra
|
CASP3 | P42574 | SOHLH1 | Homo sapiens | Q5JUK2 | 32296183 | |
|
Intra
|
CASP3 | P42574 | AKAP8 | Homo sapiens | O43823 | 16227597 | |
|
Intra
|
CASP3 | P42574 | AKAP8 | Homo sapiens | O43823 | 16227597 | |
|
Intra
|
CASP3 | P42574 | DCTN1 | Homo sapiens | Q14203-5 | 32814053 | |
|
Intra
|
CASP3 | P42574 | DCTN1 | Homo sapiens | Q14203-5 | 32814053 | |
|
Intra
|
CASP3 | P42574 | DCTN1 | Homo sapiens | Q14203-5 | 32814053 | |
|
Intra
|
CASP3 | P42574 | AKT3 | Homo sapiens | Q9Y243 | 25241761 | |
|
Intra
|
CASP3 | P42574 | AKT3 | Homo sapiens | Q9Y243 | 17544405 | |
|
Intra
|
CASP3 | P42574 | PARP1 | Homo sapiens | P09874 | 7596430 | |
|
Intra
|
CASP3 | P42574 | MDM2 | Homo sapiens | Q00987 | 25241761 | |
|
Intra
|
CASP3 | P42574 | NMT2 | Homo sapiens | O60551 | 23150525 | |
|
Intra
|
CASP3 | P42574 | HTT | Homo sapiens | P42858 | 32814053 | |
|
Intra
|
CASP3 | P42574 | HTT | Homo sapiens | P42858 | 32814053 | |
|
Intra
|
CASP3 | P42574 | HTT | Homo sapiens | P42858 | 32814053 | |
|
Intra
|
CASP3 | P42574 | CASP9 | Homo sapiens | P55211 | 18723680 | |
|
Intra
|
CASP3 | P42574 | XIAP | Homo sapiens | P98170 | 33961781 | |
|
Intra
|
CASP3 | P42574 | XIAP | Homo sapiens | P98170 | 28514442 | |
|
Intra
|
CASP3 | P42574 | XIAP | Homo sapiens | P98170 | 11257232 | |
|
Intra
|
CASP3 | P42574 | XIAP | Homo sapiens | P98170 | 25241761 | |
|
Intra
|
CASP3 | P42574 | CASP6 | Homo sapiens | P55212 | 18723680 | |
|
Intra
|
CASP3 | P42574 | CASP6 | Homo sapiens | P55212 | 25241761 | |
|
Intra
|
CASP3 | P42574 | APP | Homo sapiens | P05067 | 25241761 | |
|
Intra
|
CASP3 | P42574 | ATXN3 | Homo sapiens | P54252 | 32814053 | |
|
Intra
|
CASP3 | P42574 | ATXN3 | Homo sapiens | P54252 | 32814053 | |
|
Intra
|
CASP3 | P42574 | ATXN3 | Homo sapiens | P54252 | 32814053 |
Recombinant CASP3 Proteins
| 製品番号 | 製品名 | アクセッション番号 | 純度 |
|---|---|---|---|
| HY-P79267 | Pro-Caspase-3/Pro-CASP3 Protein, Human (277a.a, His) | AAA65015 (M1-H277) | ≥ 90%, as determined by reducing SDS-PAGE. |
CASP3 抗体
| 製品番号 | 製品名 | アプリケーション | 反応性 |
|---|---|---|---|
| HY-P80046 | Caspase-3 Antibody (YA557) | WB, ICC/IF, IHC-P, IP, FC | Human |
| HY-P80623 | Cleaved-Caspase 3 p12 Antibody (YA499) | WB, ICC/IF | Human, Mouse, Rat |
| HY-P80623A | Cleaved-Caspase 3 p12 Antibody (YA499)(PBS only) | WB, ICC/IF | Human, Mouse, Rat |
| HY-P84318 | Caspase-3 Antibody (YA4015) | WB, ELISA | Human, Mouse, Rat |
| HY-P84318A | Caspase-3 Antibody (YA4015)(PBS only) | WB, ELISA | Human, Mouse, Rat |
| HY-P84931 | Cleaved-Caspase 3 p17 Antibody (YA4628) | WB, IHC-P, ICC/IF | Human |
| HY-P85735 | Caspase-3 Antibody (YA5427) | ICC/IF, WB, IP, IHC-P | Human, Mouse, Rat, Chicken |
| HY-P86370 | Cleaved Caspase-3 (Asp175) Antibody (YA6062) | WB, IHC-P, ICC/IF, IP, ELISA | Human, Mouse, Rat |
| HY-P86633 | Caspase-3 Antibody (YA6325) | WB, IHC-P, ICC/IF, IP, ELISA | Human, Mouse, Rat |
関連疾患
| Diseases | Alias | |
|---|---|---|
| Esophageal Cancer |
|
|
| Heart Disease |
|
|
| Mantle Cell Lymphoma |
|
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| Peripheral Nervous System Neoplasm |
|
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| Rhabdomyosarcoma |
|
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| Autism |
|
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| Neuroblastoma |
|
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| Lymphadenitis |
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| Keratoacanthoma |
|
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| Ischemia |
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| Skin Carcinoma |
|
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| Hypertension, Essential |
|
|
| T-Cell Acute Lymphoblastic Leukemia |
|
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| Leukemia, Chronic Lymphocytic |
|
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| Lung Cancer Susceptibility 3 |
|
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| Severe Combined Immunodeficiency |
|
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| Spinal Cord Injury |
|
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| Panniculitis |
|
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| Oral Lichen Planus |
|
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| Autonomic Nervous System Neoplasm |
|
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| High Grade Glioma |
|
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| Pick Disease Of Brain |
|
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| Reticulosarcoma |
|
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| Leukemia, Acute Lymphoblastic |
|
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| Melanoma |
|
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| Ewing Sarcoma |
|
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| Alcoholic Cardiomyopathy |
|
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| Hepatoblastoma |
|
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| Prion Disease |
|
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| Cervix Carcinoma |
|
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| Fetal Alcohol Spectrum Disorder |
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| Asphyxia Neonatorum |
|
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| Eye Disease |
|
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| Leukemia, Acute Myeloid |
|
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| Amelogenesis Imperfecta, Type Ig |
|
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| Hepatocellular Carcinoma |
|
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| Thrombocytopenia |
|
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| Cerebral Artery Occlusion |
|
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| Malaria |
|
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| Amelogenesis Imperfecta |
|
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| Liposarcoma |
|
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| Bone Deterioration Disease |
|
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| Myocarditis |
|
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| Newcastle Disease |
|
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| Synovium Neoplasm |
|
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| Spinal Muscular Atrophy |
|
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| Colorectal Cancer |
|
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| Ataxia-Telangiectasia |
|
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| Retinal Vascular Disease |
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| Breast Cancer |
|
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| Body Mass Index Quantitative Trait Locus 11 |
|
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| Parkinson Disease, Late-Onset |
|
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| Testicular Disease |
|
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| Carotid Artery Occlusion |
|
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| Gastric Cancer |
|
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| Varicocele |
|
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| Nervous System Disease |
|
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| Premature Menopause |
|
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| Lipoprotein Quantitative Trait Locus |
|
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| Stroke, Ischemic |
|
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| Interstitial Lung Disease 2 |
|
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| Colorectal Adenocarcinoma |
|
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| Medulloblastoma |
|
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| Lung Adenoma |
|
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| Systemic Lupus Erythematosus |
|
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| Amyotrophic Lateral Sclerosis 1 |
|
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| Carbuncle |
|
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| Ovarian Cancer |
|
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| Acute Promyelocytic Leukemia |
|
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| Retinoblastoma |
|
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| Lung Cancer |
|
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| Fetal Alcohol Syndrome |
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| Congenital Nervous System Abnormality |
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| Pneumoconiosis |
|
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| Macular Degeneration, Age-Related, 1 |
|
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| Glycogen Storage Disease |
|
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| Gastric Adenocarcinoma |
|
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| Ehrlichiosis |
|
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| Muscular Atrophy |
|
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| Periventricular Leukomalacia |
|
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| Osteogenic Sarcoma |
|
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| Encephalomalacia |
|
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| Bone Cancer |
|
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| Alzheimer Disease, Familial, 1 |
|
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| Clubfoot |
|
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| Lymphangioma |
|
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| Brain Cancer |
|
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| Prostate Cancer |
|
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| Bladder Cancer |
|
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| Cystic Fibrosis |
|
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| Nephrosclerosis |
|
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| Testicular Torsion |
|
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| Teratocarcinoma |
|
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| Colon Adenocarcinoma |
|
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| Lip And Oral Cavity Cancer |
|
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| Neural Tube Defects |
|
|
| Exudative Vitreoretinopathy 1 |
|
|
| Lymphoma, Non-Hodgkin, Familial |
|
|
| Dilated Cardiomyopathy |
|
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| Type 2 Diabetes Mellitus |
|
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| Sudden Infant Death Syndrome |
|
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| Endometrial Cancer |
|
|
| Cowpox |
|
|
| Prostatitis |
|
|
| Heterophyiasis |
|
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| Tongue Disease |
|
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| Skin Papilloma |
|
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| Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex 1 |
|
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| Squamous Cell Carcinoma |
|
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| Cerebrovascular Disease |
|
|
| Bone Sarcoma |
|
|
| Renal Cell Carcinoma, Nonpapillary |
|
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| Cervical Cancer |
|
|
| Cataract |
|
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| Diabetic Encephalopathy |
|
|
| Toxic Encephalopathy |
|
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| Gallbladder Cancer |
|
|
| Breast Adenocarcinoma |
|
|
| Occlusion Precerebral Artery |
|
|
| Short-Rib Thoracic Dysplasia 4 With Or Without Polydactyly |
|
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| Myocardial Infarction |
|
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| Dysentery |
|
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| Burkitt Lymphoma |
|
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| Peripheral Nervous System Disease |
|
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| Pulmonary Emphysema |
|
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| Inflammatory Bowel Disease |
|
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| Papilloma |
|
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| Monocytic Leukemia |
|
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| Bile Duct Cancer |
|
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| Tongue Carcinoma |
|
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| Pancreatic Cancer |
|
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| Hydrocephalus |
|
|
| Autism Spectrum Disorder |
|
|
| Intracranial Berry Aneurysm |
|
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| Brain Glioblastoma Multiforme |
|
|
| Cardiomyopathy, Familial Hypertrophic, 25 |
|
|
| Lymphoma |
|
|
| Alexander Disease |
|
|
| Yellow Fever |
|
|
| Measles |
|
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| Lung Benign Neoplasm |
|
|
| Myeloma, Multiple |
|
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| Glioblastoma |
|
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| Huntington Disease |
|
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| Retinitis Pigmentosa |
|
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| Skin Disease |
|
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| Cerebral Hypoxia |
|
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| Squamous Cell Carcinoma, Head And Neck |
|
|
| Thyroid Gland Anaplastic Carcinoma |
|
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| Status Epilepticus |
|
|
| Colonic Benign Neoplasm |
|
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| B-Cell Lymphoma |
|
|
| Leukemia, Chronic Myeloid |
|
|
| Ovarian Disease |
|
|
| Tonsillitis |
|
|
| Sensory System Disease |
|
|
| Retinal Ischemia |
|
Orthologs Information
| 生物種 | Symbol | 由来 | ID |
|---|---|---|---|
| Rattus norvegicus | CASP3 | RGD | RGD:2275 |
| Mus musculus | CASP3 | MGD | MGI:107739 |
| Felis catus | CASP3 | VGNC | VGNC:60382 |
| Bos taurus | CASP3 | VGNC | VGNC:26781 |
| Canis familiaris | CASP3 | VGNC | VGNC:38734 |
| Macaca mulatta | CASP3 | VGNC | VGNC:100207 |
| Others | CASP3 | NCBI |