Golotimod
Based on 1 Customer Validation
Golotimod (SCV-07), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and splenic cell proliferation, and improves macrophage function. Golotimod (SCV-07) inhibits STAT3 signaling and modulates the duration and severity of oral mucositis in animal models that received radiation or a combination of radiation and Cisplatin. Golotimod (SCV-07) is also a potential therapeutic for recurrent genital herpes simplex virus type 2 (HSV-2).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.98%
- CAS 番号: 229305-39-9
- 分子式: C16H19N3O5
- 分子量:333.34
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保管条件:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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STAT3 |
Golotimod (SCV-07) (subcutaneous injection, once or twice a day from days 1 to 20, 100 μg/kg) can reduce the severity and duration of acute and split radiation-induced oral mucositis (OM) and short the duration of ulcerative OM in male LVG golden Syrian Hamsters[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female Hartley guinea pigs (250-300 g) infected HSV-2[1]
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Dosage:100 μg/kg
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Administration:Oral gavage or subcutaneous injection; 5 days
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Result:Reduced incidence of lesions from 55% (one week before treatment) to only 18% by oral administration, and showed no significant reduction in disease by subcutaneous injection of SCV-07.
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Animal Model:Male LVG golden Syrian Hamsters weighing approximately 80 g with radiation-induced mucositis[3]
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Dosage:10, 100 μg/kg or 1 mg/kg
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Administration:Subcutaneous injection; once or twice a day from days 1 to 20
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Result:Showed a peak mucositis of 3.0 on day 18 in the control group compared to only 2.2 in the test group, and the mucositis score in the SCV-07 treated hamsters was only 6.3% compared to 28.1% in the control group at dose of 100 μg/kg.
Significantly decreased the severity and duration of oral mucositis (OM) at dose of 10 μg/kg, 100 μg/kg or 1 mg/kg.
化学情報
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CAS 番号 229305-39-9
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性状 Solid
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分子量 333.34
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分子式 C16H19N3O5
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Color White to off-white
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別名
SCV 07; Gamma-D-glutamyl-L-tryptophan
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
溶剤 & 溶解度
H2O : 125 mg/mL (374.99 mM; Need ultrasonic)
DMSO : 50 mg/mL (150.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (278 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Rose WA 2nd, et al. An immunomodulating dipeptide, SCV-07, is a potential therapeutic for recurrent genital herpes simplex virus type 2 (HSV-2). Int J Antimicrob Agents. 2008 Sep;32(3):262-6. [Content Brief]
[2]. Geiger JL, et al. The STAT3 pathway as a therapeutic target in head and neck cancer: Barriers and innovations. Oral Oncol. 2016 May;56:84-92. [Content Brief]
[3]. Watkins B, et al. Attenuation of radiation- and chemoradiation-induced mucositis using gamma-D-glutamyl-L-tryptophan (SCV-07). Oral Dis. 2010 Oct;16(7):655-60. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 2.9999 mL | 14.9997 mL | 29.9994 mL | 74.9985 mL |
| 5 mM | 0.6000 mL | 2.9999 mL | 5.9999 mL | 14.9997 mL | |
| 10 mM | 0.3000 mL | 1.5000 mL | 2.9999 mL | 7.4999 mL | |
| 15 mM | 0.2000 mL | 1.0000 mL | 2.0000 mL | 4.9999 mL | |
| 20 mM | 0.1500 mL | 0.7500 mL | 1.5000 mL | 3.7499 mL | |
| 25 mM | 0.1200 mL | 0.6000 mL | 1.2000 mL | 2.9999 mL | |
| 30 mM | 0.1000 mL | 0.5000 mL | 1.0000 mL | 2.5000 mL | |
| 40 mM | 0.0750 mL | 0.3750 mL | 0.7500 mL | 1.8750 mL | |
| 50 mM | 0.0600 mL | 0.3000 mL | 0.6000 mL | 1.5000 mL | |
| 60 mM | 0.0500 mL | 0.2500 mL | 0.5000 mL | 1.2500 mL | |
| 80 mM | 0.0375 mL | 0.1875 mL | 0.3750 mL | 0.9375 mL | |
| 100 mM | 0.0300 mL | 0.1500 mL | 0.3000 mL | 0.7500 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Golotimod 関連分類
HY-14743 関連分類
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