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製品番号: HY-112453

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IMDNQ1

IMDNQ1 is a Trypanosoma cruzi inhibitor derived from 1,4-naphthoquinone substituted with cyclic imide. IMDNQ1 effectively inhibits the proliferation of Trypanosoma cruzi epimastigotes, while also reducing the viability of mouse fibroblasts. The selectivity index between the antiproliferative activity and cytotoxicity of IMDNQ1 is 60.25, indicating a certain level of safety. IMDNQ1 can be widely used in studies related to Chagas disease.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 623163-52-0
分子式: C₁₄H₈ClNO₄
分子量:289.67

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

IMDNQ1 構造式

CAS 番号: 623163-52-0

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

HY-132844
Tunlametinib

MEK1/2 Inhibitor

生物活性

製品説明

Parasite アイソフォーム固有の製品をすべて表示 :

体外実験

IMDNQ1 (0.39-100 μM; 48 h) exhibits low cytotoxicity to Balb/C 3T3 mouse fibroblasts with an IC₅₀ of 165.9 μM, resulting in a selectivity index of 60.25 that is significantly higher than Nifurtimox (HY-W040073)^[1].
IMDNQ1 (0.39-100 µM; 48 h) potently inhibits the proliferation of Trypanosoma cruzi epimastigotes (Tulahuen CL98 strain) with an IC₅₀ of 2.77 µM, showing significantly greater activity than Nifurtimox (HY-W040073)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[2]

Cell Line:

Balb/C 3T3 mouse fibroblasts (clone A31)
Concentration:

0.39-100 µM
Incubation Time:

48 h
Result:

Reduced the viability of Balb/C 3T3 mouse fibroblasts with an IC₅₀ of 165.9 µM.
Exhibited significantly less cytotoxicity than nifurtimox (IC₅₀=114.0 µM).
Achieved a selectivity index of 60.25, which is significantly higher than the selectivity index of nifurtimox.

Related Protocols :

化学情報

CAS 番号 623163-52-0
分子量 289.67
分子式 C₁₄H₈ClNO₄
SMILES

O=C1C(Cl)=C(C(=O)C=2C=CC=CC12)N3C(=O)CCC3=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Khraiwesh MH, et al. Antitrypanosomal activities and cytotoxicity of some novel imido-substituted 1,4-naphthoquinone derivatives. Arch Pharm Res. 2012;35(1):27-33. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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濃度濃度

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分子量分子量

希釈計算機

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濃度 _(開始) 濃度 _(開始)

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濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Minimum order quantity

100 mg

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