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製品番号: HY-N21743

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Kalmanol

Kalmanol is a kalmane-type diterpenoid found in Rhododendri Mollis Flos and the leaves of Schinus terebinthifolius. Kalmanol is a state-dependent inhibitor of NaV_1.4 channels, and upon binding to inactivated channels, it shifts the fast inactivation curve toward hyperpolarized potentials. Kalmanol exhibits analgesic activity and is used in pain-related research.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 118997-92-5
分子式: C₂₀H₃₄O₆
分子量:370.48

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Kalmanol 構造式

CAS 番号: 118997-92-5

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
- 体外実験
- 体内実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target

^[1]

hNa_v1.4

Sodium Channel アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC50	199.3 μM	Inhibitory effect on human voltage-gated sodium channel NaV1.4 in resting state expressed in CHO cells measured by electrophysiological recordings. Inhibitory effect on human voltage-gated sodium channel NaV1.4 in resting state expressed in CHO cells measured by electrophysiological recordings.	39082673
CHO	IC50	19.6 μM	Inhibitory effect on human voltage-gated sodium channel NaV1.4 in half-inactivated state expressed in CHO cells measured by electrophysiological recordings. Inhibitory effect on human voltage-gated sodium channel NaV1.4 in half-inactivated state expressed in CHO cells measured by electrophysiological recordings.	39082673

体外実験

Kalmanol is one of the seven key toxic components of Rhododendron molle; network toxicology analysis suggests that it acts on a total of 12 target proteins, including AR, ALB, ESR2, SHBG, HSD17B11, ESR1, RXRG, LDHC, AKR1C3, ABCB1, UGT2B7, and GLUL^[1].
Kalmanol (compound 5) (0.025 mmol; 10 h) undergoes chemical transformation under acid-promoted conditions using PPTS in t-BuOH to yield Seco-rhodomollone, Rhodomollein XXIV, and Rhodomollein XXIII^[2].
Kalmanol is a state-dependent inhibitor of human Na_V1.4 channels expressed in CHO cells, with IC₅₀ values of 199.3 μM and 19.6 μM for the resting and half-inactivated states, respectively; it shifts the voltage dependence of fast inactivation of Na_V1.4 by approximately 17 mV toward hyperpolarized potentials^[4].
Kalmanol exhibits strong binding affinity with Saccharomyces cerevisiae α-glucosidase (MAL32), inducible nitric oxide synthase (iNOS), and antioxidant pathway-related proteins 2CDU and 3RP8 in molecular docking simulations^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Kalmanol (compound 8) (0.04-1 mg/kg) exhibits potent analgesic activity, with a writhing inhibition rate of 54.7% at a dose as low as 0.04 mg/kg^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 118997-92-5
分子量 370.48
分子式 C₂₀H₃₄O₆
SMILES

O[C@@]12[C@@]3([H])[C@](CC[C@@]3([H])[C@](O)(C2)C)([H])[C@@](O)([C@@]4([H])[C@]([C@@H](C1)O)(C(C)([C@H](C4)O)C)O)C
Structure Classification
- Terpenoids
- Diterpenoids
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Guo XH, et al. [Toxicity mechanism of Rhododendri Mollis Flos: based on serum metabolomics and network toxicology]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 Apr;47(7):1932-1941.

[2]. Tsuruyama T, et al. Bioinspired Chemical Transformations of Grayanotoxin III to Kalmanol, -Rhodomollone, and Rhodomolleins XXIII and XXIV. Journal of natural products. 2026 Jan 23;89(1):161-169.

[3]. Feng Y, et al. Discovery of kalmane diterpenoids as potent analgesics from the flowers of Rhododendron dauricum. Chinese Journal of Chemistry. 2022 May 1;40(9):1019-27.

[4]. Ma T, et al. Total Synthesis of (+)-Kalmanol. Angewandte Chemie (International ed. in English). 2024 Oct 14;63(42):e202407215.

[5]. Nguyen VK, et al. Free and bound phenolic extracts of Schinus terebinthifolius leaves: phytochemical profiling and in vitro–in silico bioactivity investigations. Natural Product Research. 2026 Mar 6:1-6.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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