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Others Stem Cell/Wnt MAPK/ERK Pathway JAK/STAT Signaling Metabolic Enzyme/Protease TGF-beta/Smad NF-κB Protein Tyrosine Kinase/RTK Epigenetics Immunology/Inflammation Apoptosis Neuronal Signaling GPCR/G Protein
Reference Standards ERK STAT Phosphodiesterase (PDE) PKA p38 MAPK Keap1-Nrf2 JAK Interleukin Related Apoptosis Cannabinoid Receptor
Linderane (Standard)

製品番号: HY-N0688R

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Linderane (Standard)

Linderane (Standard) is the analytical standard of Linderane (HY-N0688). This product is intended for research and analytical applications. Linderane is an orally active natural sesquiterpene lactone with blood-brain barrier permeability. Linderane indirectly activates PDE3 by activating ERK/STAT3, thereby inhibiting the cAMP/PKA/CREB signaling pathway and hepatic gluconeogenesis. Linderane protects pancreatic β cells against oxidative damage by inhibiting the activation of the p38 MAPK pathway and activating the Nrf2 pathway. Linderane inhibits cell apoptosis and ameliorates intestinal mucosal inflammation by suppressing the IL-6/JAK/STAT3 signaling pathway. Linderane reduces pain sensitivity and alleviates anxiety-like behaviors by activating cannabinoid receptor 2 (CB2R). Linderane can be used in studies related to type 2 diabetes, ulcerative colitis, and chronic inflammatory pain with anxiety.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 13476-25-0
分子式: C₁₅H₁₆O₄
分子量:260.29

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Linderane (Standard) 構造式

CAS 番号: 13476-25-0

容量

価格（税別）

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数量

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Product Information

説明

アプリケーション

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

化学情報

CAS 番号 13476-25-0
分子量 260.29
分子式 C₁₅H₁₆O₄
SMILES

O=C(O[C@@]1([H])C2=C3OC=C2C)C4(CC/C=C(C)\C3)[C@@H]1O4
Structure Classification
- Terpenoids
- Sesquiterpenes
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

参考文献

[1]. Xie W, et al. Linderane Suppresses Hepatic Gluconeogenesis by Inhibiting the cAMP/PKA/CREB Pathway Through Indirect Activation of PDE 3 via ERK/STAT3. Frontiers in pharmacology. 2018;9:476. [Content Brief]

[2]. Zhang H, et al. Linderane protects pancreatic β cells from streptozotocin (STZ)-induced oxidative damage. Life sciences. 2019 Sep 15;233:116732. [Content Brief]

[3]. Lai H, et al. Linderane from Lindera aggregata attenuates ulcerative colitis by suppressing IL-6/STAT3-mediated Th17 differentiation and apoptosis resistance. Journal of ethnopharmacology. 2026 Feb 28;357:120965. [Content Brief]

[4]. Chen Y, et al. Linderane Attenuates Complete Freund's Adjuvant-Induced Pain and Anxiety in Mice by Restoring Anterior Cingulate Cortex Microglia M2 Polarization through Activating Cannabinoid 2 Receptor. ACS pharmacology & translational science. 2024 Mar 08;7(3):797-808. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

100 mg

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