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製品番号: HY-182533

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LN5972

LN5972 is a selective ACKR3 agonist with an EC₅₀ of 3.40 μM, showing higher selectivity for ACKR3 over CXCR4. LN5972 induces β-arrestin recruitment to ACKR3/CXCR7. LN5972 reduces the surface expression of P-selectin. LN5972 is applicable to studies related to platelet-mediated thrombosis.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 3035425-93-2
分子式: C₁₉H₃₀N₆O₃S
分子量:422.54

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

LN5972 構造式

CAS 番号: 3035425-93-2

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
- アプリケーション
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
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生物活性

製品説明

IC₅₀ & Target

^[1]

ACKR3

3.40 μM (EC₅₀)

CXCR アイソフォーム固有の製品をすべて表示 :

体外実験

LN5972 (0.3 nM-100 μM) acts as a superagonist for ACKR3 in HEK293T cells, inducing β-arrestin recruitment with an EC₅₀ of 3.40 μM and a maximal efficacy 161% that of CXCL12^[1].
LN5972 (100 μM; 15 min preincubation) reduces CRP-XL-induced P-selectin expression by 76% in human platelet-rich plasma^[1].
LN5972 (0.3 nM-100 μM) is selective for ACKR3 and shows no activity at CXCR4 in HEK293T cells^[1].
LN5972 shows high metabolic stability in human liver microsomes (87% remaining at 120 min) and reduced stability in mouse liver microsomes^[1].
LN5972 (up to 100 μM; 72 h) is non-cytotoxic to THP1 and HEK293 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

アプリケーション

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

化学情報

CAS 番号 3035425-93-2
分子量 422.54
分子式 C₁₉H₃₀N₆O₃S
SMILES

O=C(N1CCN(CCCNC2=NN3C(C=C(CC)N=C3S2)=O)CC1)OC(C)(C)C
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Bayrak A, et al. Discovery and Development of First-in-Class ACKR3/CXCR7 Superagonists for Platelet Degranulation Modulation. J Med Chem. 2022;65(19):13365-13384. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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