Methylliberine
Based on 1 Customer Validation
Methylliberine is an orally active adenosine A1 receptor modulator. Methylliberine inhibits spermatogenesis and induces testicular atrophy.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.94%
- CAS 番号: 51168-26-4
- 分子式: C9H12N4O3
- 分子量:224.22
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Adenosine Receptor アイソフォーム固有の製品をすべて表示
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生物活性
製品説明
体外実験
Methylliberine (125-2000 µg/mL; 3-28 h) is non-clastogenic in V79 male Chinese hamster lung cells under short-term exposure up to 2000 µg/mL and long-term exposure up to 500 µg/mL, with and without S9 metabolic activation[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
臨床実験
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | 2011-05 | PHASE1 |
化学情報
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CAS 番号 51168-26-4
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性状 Solid
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分子量 224.22
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分子式 C9H12N4O3
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Color White to off-white
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SMILES
O=C1C2=C(N(C)C(N2C)=O)N=C(N1C)OC
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
体外:
DMSO : 1 mg/mL (4.46 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (284 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Tartar JL, et al. A Combination of Caffeine, TeaCrine® (Theacrine), and Dynamine® (Methylliberine) Increases Cognitive Performance and Reaction Time Without Interfering With Mood in Adult Male Egamers. Cureus. 2021 Dec;13(12):e20534. [Content Brief]
[5]. Murbach TS, et al. A Toxicological Evaluation of Methylliberine (Dynamine®). Journal of toxicology. 2019;2019:4981420. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.4599 mL | 22.2995 mL | 44.5991 mL | 111.4976 mL |
Methylliberine 関連分類
HY-N7564 関連分類
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Keywords
- Methylliberine
- 51168-26-4
- Adenosine Receptor
- 1,3,7-trimethylxanthine catabolism
- C-8 oxidation pathway
- S9 metabolic activation
- adenosine A1 receptor
- adenosine receptors
- bacterial reverse mutation test
- bone marrow micronucleus test
- mammalian chromosomal aberration test
- spermatogenesis
- testicular atrophy
- Inhibitor
- inhibitor
- inhibit