MK-0359
MK-0359 (L-454,560) is a selective and orally active PDE4 inhibitor, and can be used for asthma and chronic obstructive pulmonary disease (COPD) research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 346629-30-9
- 分子式: C31H29N3O5S2
- 分子量:587.71
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
49.9 μM
Compound: 3
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Displacement of [35S]MK-499 from human ERG expressed in HEK293 cells
Displacement of [35S]MK-499 from human ERG expressed in HEK293 cells
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[PMID: 18835163] |
| Sf21 | IC50 |
3.9 μM
Compound: 4, L-454560
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Inhibition of His-tagged catalytic domain Trypanosoma brucei brucei PDEB2 expressed in baculovirus infected insect Sf21 cells
Inhibition of His-tagged catalytic domain Trypanosoma brucei brucei PDEB2 expressed in baculovirus infected insect Sf21 cells
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[PMID: 22023548] |
| Sf21 | IC50 |
8.8 μM
Compound: 4, L-454560
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Inhibition of His-tagged catalytic domain Trypanosoma brucei brucei PDEB1 expressed in baculovirus infected insect Sf21 cells
Inhibition of His-tagged catalytic domain Trypanosoma brucei brucei PDEB1 expressed in baculovirus infected insect Sf21 cells
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[PMID: 22023548] |
| Sf9 | IC50 |
1.4 nM
Compound: 3
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Intrinsic inhibition of GST-fused human PDE4A expressed in SF9 cells
Intrinsic inhibition of GST-fused human PDE4A expressed in SF9 cells
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[PMID: 18835163] |
| Sf9 | IC50 |
3 nM
Compound: 1, L-454560
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Inhibition of PDE4 expressed in SF9 cells
Inhibition of PDE4 expressed in SF9 cells
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[PMID: 18207397] |
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 346629-30-9
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分子量 587.71
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分子式 C31H29N3O5S2
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SMILES
O=S(C1=CC=C(/C(C2=NC(C)=NO2)=C\C3=CC(C4=C5N=CC=CC5=CC(C(S(=O)(C)=O)(C)C)=C4)=CC=C3)C=C1)(C)=O
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別名
L-454,560
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
MK-0359 関連分類
HY-11072 関連分類
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