MRL-871
Based on 1 publication(s) in Google Scholar
MRL-871 (compound 3) is a potent and allosteric retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonists with an IC50 of 12.7 nM. MRL-871 has a distinct isoxazole chemotype and effectively reduces IL-17a mRNA production in EL4 cells.
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- 純度: 99.11%
- CAS 番号: 1392809-08-3
- 分子式: C22H12ClF3N2O3
- 分子量:444.79
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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MedChemExpress（MCE）の使用を引用している文献 MRL-871
More
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| PBMC | IC50 |
39.6 nM
Compound: 39; PDB 4YPQ, MRL-871
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Inhibition of IL17 production in human PBMC cells measured after 4 days by enzyme-linked immunosorbent assay
Inhibition of IL17 production in human PBMC cells measured after 4 days by enzyme-linked immunosorbent assay
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[PMID: 30010338] |
化学情報
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CAS 番号 1392809-08-3
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性状 Solid
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分子量 444.79
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分子式 C22H12ClF3N2O3
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Color White to off-white
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SMILES
O=C(C1=CC=C(C=C1)C2=NN(C3=C2C=CC=C3)C(C4=C(C=CC=C4Cl)C(F)(F)F)=O)O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Antiviral Res
Validation of nuclear receptor RORγ isoform 1 as a novel host-directed antiviral target based on the modulation of cholesterol levels. [Abstract]2024 Jan:221:105769. PMID: 38056603
溶剤 & 溶解度
DMSO : 25 mg/mL (56.21 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (275 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2483 mL | 11.2413 mL | 22.4825 mL | 56.2063 mL |
| 5 mM | 0.4497 mL | 2.2483 mL | 4.4965 mL | 11.2413 mL | |
| 10 mM | 0.2248 mL | 1.1241 mL | 2.2483 mL | 5.6206 mL | |
| 15 mM | 0.1499 mL | 0.7494 mL | 1.4988 mL | 3.7471 mL | |
| 20 mM | 0.1124 mL | 0.5621 mL | 1.1241 mL | 2.8103 mL | |
| 25 mM | 0.0899 mL | 0.4497 mL | 0.8993 mL | 2.2483 mL | |
| 30 mM | 0.0749 mL | 0.3747 mL | 0.7494 mL | 1.8735 mL | |
| 40 mM | 0.0562 mL | 0.2810 mL | 0.5621 mL | 1.4052 mL | |
| 50 mM | 0.0450 mL | 0.2248 mL | 0.4497 mL | 1.1241 mL |
MRL-871 関連分類
HY-119464 関連分類
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