MTOB (sodium)
Based on 2 publication(s) in Google Scholar
MTOB sodium is a potent C-terminal binding protein (CtBP) inhibitor. MTOB sodium attenuates repetitive head injury-elicited neurologic dysfunction and neuroinflammation via inhibition of the transactivation activity of CtBP1 and CtBP2. MTOB sodium antagonizes the transcriptional regulatory activity of CtBP1 and CtBP2 by eviction from their target promoters in breast cancer cell lines.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 97.02%
- CAS 番号: 51828-97-8
- 分子式: C5H7NaO3S
- 分子量:170.16
-
保管条件:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
-
溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
-
Cell Cycle/DNA Damage Compound Library
HY-L004
-
Immunology/Inflammation Compound Library
HY-L007
-
Anti-Cancer Compound Library
HY-L025
-
Anti-Aging Compound Library
HY-L034
-
Anti-Breast Cancer Compound Library
HY-L074
-
Bioactive Compound Library Max
HY-L181
-
MCE Bioactive Compound Library
HY-L001V
-
Bioactive Compound Library
HY-L001
-
High-Throughput Bioactive Compound Library
HY-L205
-
Flavors and Fragrances Compound Library
HY-L242
MedChemExpress（MCE）の使用を引用している文献 MTOB sodium
MoreDNA/RNA Synthesis アイソフォーム固有の製品をすべて表示
More
生物活性
CtBP[1]
MTOB sodium (10 mM) causes significant derepression (P<0.05) of 40% of CtBP target genes (including FGF9, CTNNB1, CEBPB, et al.) in MCF-7 and 46% in MBA-MD-231; increases the pro-epithelial E-cadherin/Vimentin ratio while reducing the pro-mesenchymal CD44/CD24 ratio, with a more significant trend (P<0.05) in MCF-7[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:C57BL/6 mice (traumatic brain injury)[1]
-
Dosage:860 mg/kg
-
Administration:IP, at 1 h and 18 h after the first injury
-
Result:Effectively suppressed the increased duration of righting reflex, and significantly decreased NSS scores.
化学情報
-
CAS 番号 51828-97-8
-
性状 Solid
-
分子量 170.16
-
分子式 C5H7NaO3S
-
Color White to off-white
-
SMILES
O=C(O[Na])C(CCSC)=O
-
別名
α-ケト-γ-(メチルチオ)酪酸 ナトリウム塩
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (2)
-
Journal Impact Factor
-
Most Recent
-
Biol Direct
PNSC928, a plant-derived compound, specifically disrupts CtBP2-p300 interaction and reduces inflammation in mice with acute respiratory distress syndrome. [Abstract]2024 Jun 21;19(1):48. PMID: 38902802 -
Cytokine
Suppression of DNMT2/3 by proinflammatory cytokines inhibits CtBP1/2-dependent genes to promote the occurrence of atrophic nonunion. [Abstract]2024 Jan:173:156436. PMID: 37979214
溶剤 & 溶解度
H2O : 200 mg/mL (1175.36 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
-
データシート (272 KB)
-
SDS (453 KB)
- English - EN (453 KB)
- Français - FR (453 KB)
- Deutsch - DE (453 KB)
- Norwegian - NO (453 KB)
- Español - ES (453 KB)
- Swedish - SV (453 KB)
- Italian - IT (453 KB)
- Korean - KR (453 KB)
- Portuguese - PT (453 KB)
-
取扱説明書 (2659 KB)
参考文献
[1]. Li H, et al. C-terminal binding proteins 1 and 2 in traumatic brain injury-induced inflammation and their inhibition as an approach for anti-inflammatory treatment. Int J Biol Sci. 2020 Feb 4;16(7):1107-1120. [Content Brief]
[2]. Di LJ, et al. Genome-wide profiles of CtBP link metabolism with genome stability and epithelial reprogramming in breast cancer. Nat Commun. 2013;4:1449. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 5.8768 mL | 29.3841 mL | 58.7682 mL | 146.9205 mL |
| 5 mM | 1.1754 mL | 5.8768 mL | 11.7536 mL | 29.3841 mL | |
| 10 mM | 0.5877 mL | 2.9384 mL | 5.8768 mL | 14.6921 mL | |
| 15 mM | 0.3918 mL | 1.9589 mL | 3.9179 mL | 9.7947 mL | |
| 20 mM | 0.2938 mL | 1.4692 mL | 2.9384 mL | 7.3460 mL | |
| 25 mM | 0.2351 mL | 1.1754 mL | 2.3507 mL | 5.8768 mL | |
| 30 mM | 0.1959 mL | 0.9795 mL | 1.9589 mL | 4.8974 mL | |
| 40 mM | 0.1469 mL | 0.7346 mL | 1.4692 mL | 3.6730 mL | |
| 50 mM | 0.1175 mL | 0.5877 mL | 1.1754 mL | 2.9384 mL | |
| 60 mM | 0.0979 mL | 0.4897 mL | 0.9795 mL | 2.4487 mL | |
| 80 mM | 0.0735 mL | 0.3673 mL | 0.7346 mL | 1.8365 mL | |
| 100 mM | 0.0588 mL | 0.2938 mL | 0.5877 mL | 1.4692 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
MTOB sodium 関連分類
HY-135046 関連分類
Powered by Bioz