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製品番号: HY-155785

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MTP

MTP is a PKM2 inhibitor. MTP induces cancer cell apoptosis by modulating caspase-3 activation. MTP induces autophagy and increases ROS generation. MTP also inhibits JAK2 signaling. MTP can be used for research of oral squamous cell carcinoma.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 2377372-62-6
分子式: C₂₉H₂₃F₃N₄O₂
分子量:516.51

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

MTP 構造式

CAS 番号: 2377372-62-6

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
- 臨床実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target

JAK2

JAK アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
LNCaP	IC₅₀	>2 μM Compound: 1; Tr-87	Antiproliferative activity against human LNCAP cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Antiproliferative activity against human LNCAP cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 31465224]
MCF7	IC₅₀	1 μM Compound: 1; Tr-87	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 31465224]
MDA-MB-231	IC₅₀	0.1 μM Compound: 1; Tr-87	Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 31465224]
NCI-H157	IC₅₀	>2 μM Compound: 1; Tr-87	Antiproliferative activity against human NCI-H157 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Antiproliferative activity against human NCI-H157 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 31465224]
NCI-H157	IC₅₀	>2 μM Compound: 1; Tr-87	Antiproliferative activity against human NCI-H157 cells expressing wild type EGFR assessed as reduction in cell viability incubated for 24 hrs by MTT assay Antiproliferative activity against human NCI-H157 cells expressing wild type EGFR assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 31465224]
NCI-H1650	IC₅₀	0.2 μM Compound: 1; Tr-87	Antiproliferative activity against human NCI-H1650 cells harboring EGFR mutant assessed as reduction in cell viability incubated for 24 hrs by MTT assay Antiproliferative activity against human NCI-H1650 cells harboring EGFR mutant assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 31465224]
NCI-H1975	IC₅₀	1 μM Compound: 1; Tr-87	Antiproliferative activity against human NCI-H1975 cells harboring EGFR mutant assessed as reduction in cell viability incubated for 24 hrs by MTT assay Antiproliferative activity against human NCI-H1975 cells harboring EGFR mutant assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 31465224]
NCI-H460	IC₅₀	1.5 μM Compound: 1; Tr-87	Antiproliferative activity against human H460 cells expressing wild type EGFR assessed as reduction in cell viability incubated for 24 hrs by MTT assay Antiproliferative activity against human H460 cells expressing wild type EGFR assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 31465224]
PC-3	IC₅₀	0.6 μM Compound: 1; Tr-87	Antiproliferative activity against human PC3 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Antiproliferative activity against human PC3 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 31465224]
PC-9	IC₅₀	0.5 μM Compound: 1; Tr-87	Antiproliferative activity against human PC9 cells harboring EGFR mutant assessed as reduction in cell viability incubated for 24 hrs by MTT assay Antiproliferative activity against human PC9 cells harboring EGFR mutant assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 31465224]

臨床実験

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

化学情報

CAS 番号 2377372-62-6
分子量 516.51
分子式 C₂₉H₂₃F₃N₄O₂
SMILES

C#CC(NC1=CC=C(C=C1)N2N=C(C=C2C3=CC=C(C=C3)C4=CC=C(C=C4)C(F)(F)F)CCC(NC)=O)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (268 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Weng JR, et al. A PKM2 inhibitor induces apoptosis and autophagy through JAK2 in human oral squamous cell carcinoma cells. Chem Biol Interact. 2023 Aug 1;380:110538. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Other size

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Amount: USD 0.00

生物活性
- 製品説明
- IC₅₀ & Target
- 臨床実験
化学情報
純度とドキュメンテーション
参考文献

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MTP

JAK アイソフォーム固有の製品をすべて表示