NSC15520
Based on 1 Customer Validation
NSC15520 is a small molecular inhibitor of Replication Protein A (RPA). NSC15520 specifically recognizes the RPA N-terminal DNA binding domain (DBD), and blocks the interaction of RPA with p53 or RAD9. NSC15520 also inhibtis helix destabilization of a duplex DNA (dsDNA) oligonucleotide, involves in DNA replication, DNA repair, DNA recombination, and DNA damage response signaling.
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- 純度: 99.90%
- CAS 番号: 730960-98-2
- 分子式: C24H34O6
- 分子量:418.52
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保管条件:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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DNA/RNA Synthesis アイソフォーム固有の製品をすべて表示
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生物活性
NSC15520 (10-.5-10-3.5 M) inhibits the interaction of RPA with GST-p53 peptide with an IC50 value of 10 μM[1].
NSC15520 (0-400 μM; 5 min) inhibits helix destabilization activity[1].
NSC15520 (0-400 μM; 5 min) inhibits RPA binding of a dsDNA 30-mer[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 730960-98-2
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性状 Solid
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分子量 418.52
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分子式 C24H34O6
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Color White to off-white
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SMILES
C[C@@]1(C(O)=O)CCC[C@]2(C)[C@]3([H])[C@]4(C(C(O)=O)[C@H]([C@@H](C3)C(C(C)C)=C4)C(O)=O)CC[C@@]12[H]
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
溶剤 & 溶解度
DMSO : 30 mg/mL (71.68 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (278 KB)
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SDS (252 KB)
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- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3894 mL | 11.9469 mL | 23.8937 mL | 59.7343 mL |
| 5 mM | 0.4779 mL | 2.3894 mL | 4.7787 mL | 11.9469 mL | |
| 10 mM | 0.2389 mL | 1.1947 mL | 2.3894 mL | 5.9734 mL | |
| 15 mM | 0.1593 mL | 0.7965 mL | 1.5929 mL | 3.9823 mL | |
| 20 mM | 0.1195 mL | 0.5973 mL | 1.1947 mL | 2.9867 mL | |
| 25 mM | 0.0956 mL | 0.4779 mL | 0.9557 mL | 2.3894 mL | |
| 30 mM | 0.0796 mL | 0.3982 mL | 0.7965 mL | 1.9911 mL | |
| 40 mM | 0.0597 mL | 0.2987 mL | 0.5973 mL | 1.4934 mL | |
| 50 mM | 0.0478 mL | 0.2389 mL | 0.4779 mL | 1.1947 mL | |
| 60 mM | 0.0398 mL | 0.1991 mL | 0.3982 mL | 0.9956 mL |
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