Paramethasone
Paramethasone is an orally active long-acting glucocorticoid. Paramethasone directly inhibits testicular aromatase, thereby reducing the synthesis of estradiol. Paramethasone suppresses the basal and midcycle luteinizing hormone surges in female animals and blocks estrogen synthesis. Paramethasone also decreases circulating levels of dihydrotestosterone, androstenedione and estradiol in male animals. Paramethasone inhibits cartilage degeneration and alleviates joint pathological damage in osteoarthritis models. Paramethasone can be used in research related to osteoarthritis and endocrinology.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 53-33-8
- 分子式: C22H29FO5
- 分子量:392.46
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:New Zealand white (male, ~4 kg, surgically induced model)[2]
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Dosage:0.1 mg/kg
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Administration:p.o.; 5 days per week; 5 weeks
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Result:Reduced global lesion scores for tibial and femoral cartilage significantly relative to controls.
Maintained cartilage architecture.
Partially prevented chondrocyte loss and stainable proteoglycan loss.
Markedly reduced the incidence and severity of osteophytes.
Reduced the size and number of chondrocyte clones.
Lowered the incidence and severity of ulcers and fissures.
化学情報
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CAS 番号 53-33-8
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分子量 392.46
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分子式 C22H29FO5
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SMILES
C[C@@]12[C@](C[C@H]([C@]2(O)C(CO)=O)C)([H])[C@@]3([H])[C@@]([C@H](C1)O)([H])[C@@]4(C([C@H](C3)F)=CC(C=C4)=O)C
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Cortés-Gallegos V, et al. Paramethasone acetate (PA): corticosteroid potency vs hypothalamic pituitary-gonadal axis. J Steroid Biochem. 1984;20(1):353-356. [Content Brief]
[2]. Colombo C, et al. A new model of osteoarthritis in rabbits. II. Evaluation of anti-osteoarthritic effects of selected antirheumatic drugs administered systemically. Arthritis Rheum. 1983 Sep;26(9):1132-9. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Paramethasone 関連分類
HY-A0179 関連分類
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