Piperin-d10
Piperin-d10 is deuterium labeled Piperine. Piperine is an alkaloid, can be isolated from pepper. Piperine can inhibit the activity of P-glycoprotein and CYP3A4. Piperine inhibits HeLa cells with an IC50 of 61.94±0.054 μg/mL.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C17H9D10NO3
- 分子量:295.40
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Endogenous Metabolite アイソフォーム固有の製品をすべて表示
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生物活性
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
化学情報
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非標識Cas 94-62-2
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分子量 295.40
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分子式 C17H9D10NO3
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SMILES
O=C(N1C([2H])(C([2H])(C([2H])(C([2H])(C1([2H])[2H])[2H])[2H])[2H])[2H])/C=C/C=C/C2=CC=C3OCOC3=C2
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別名
Bioperine-d10; 1-Piperoylpiperidine-d10
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
溶剤 & 溶解度
DMSO : 50 mg/mL (169.26 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. Paarakh PM, et al. In vitro cytotoxic and in silico activity of piperine isolated from Piper nigrum fruits Linn. In Silico Pharmacol. 2015 Dec;3(1):9. Epub 2015 Oct 29. [Content Brief]
[3]. Meghwal M,et al. Piper nigrum and piperine: an update. Phytother Res. 2013 Aug;27(8):1121-30. [Content Brief]
[4]. Li C, et al. Non-linear pharmacokinetics of piperine and its herb-drug interactions with docetaxel in Sprague-Dawley rats. J Pharm Biomed Anal. 2016 Sep 5;128:286-93. [Content Brief]
[5]. Zhai WJ, et al. Piperine Plays an Anti-Inflammatory Role in Staphylococcus aureus Endometritis by Inhibiting Activation of NF-κB and MAPK Pathways in Mice. Evid Based Complement Alternat Med. 2016;2016:8597208. [Content Brief]
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.3852 mL | 16.9262 mL | 33.8524 mL | 84.6310 mL |
| 5 mM | 0.6770 mL | 3.3852 mL | 6.7705 mL | 16.9262 mL | |
| 10 mM | 0.3385 mL | 1.6926 mL | 3.3852 mL | 8.4631 mL | |
| 15 mM | 0.2257 mL | 1.1284 mL | 2.2568 mL | 5.6421 mL | |
| 20 mM | 0.1693 mL | 0.8463 mL | 1.6926 mL | 4.2316 mL | |
| 25 mM | 0.1354 mL | 0.6770 mL | 1.3541 mL | 3.3852 mL | |
| 30 mM | 0.1128 mL | 0.5642 mL | 1.1284 mL | 2.8210 mL | |
| 40 mM | 0.0846 mL | 0.4232 mL | 0.8463 mL | 2.1158 mL | |
| 50 mM | 0.0677 mL | 0.3385 mL | 0.6770 mL | 1.6926 mL | |
| 60 mM | 0.0564 mL | 0.2821 mL | 0.5642 mL | 1.4105 mL | |
| 80 mM | 0.0423 mL | 0.2116 mL | 0.4232 mL | 1.0579 mL | |
| 100 mM | 0.0339 mL | 0.1693 mL | 0.3385 mL | 0.8463 mL |
Piperin-d10 関連分類
HY-W654320 関連分類
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