Piroxantrone
Piroxantrone (Oxantrazole) is a potent DNA topoisomerase II-targeting anthrapyrazole antitumor agent. Piroxantrone displays cardiotoxicity.
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- CAS 番号: 91441-23-5
- 分子式: C21H25N5O4
- 分子量:411.45
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Topoisomerase アイソフォーム固有の製品をすべて表示
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生物活性
製品説明
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| K562 | IC50 |
4 μM
Compound: Piroxantrone
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Growth inhibition of human K562 cells after 72 hrs by MTS method
Growth inhibition of human K562 cells after 72 hrs by MTS method
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[PMID: 18258442] |
化学情報
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CAS 番号 91441-23-5
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分子量 411.45
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分子式 C21H25N5O4
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SMILES
O=C1C2=C3C(N(N=C3C4=C(C=CC(O)=C14)O)CCNCCO)=CC=C2NCCCN
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別名
Oxantrazole; NCS 349174
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Hasinoff BB, et al. The displacement of iron(III) from its complexes with the anticancer drugs piroxantrone and losoxantrone by the hydrolyzed form of the cardioprotective agent dexrazoxane. J Inorg Biochem. 1999 Nov-Dec;77(3-4):257-9. [Content Brief]
[2]. Frank SK, et al. Preclinical pharmacology of the anthrapyrazole analog oxantrazole (NSC-349174, piroxantrone). Cancer Chemother Pharmacol. 1989;23(4):213-8. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Piroxantrone 関連分類
HY-13726 関連分類
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