Propamidine
Based on 1 Customer Validation
Propamidine is a covalent inhibitor of TMPRSS2 and has some antibacterial activity..
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 96.15%
- CAS 番号: 104-32-5
- 分子式: C17H20N4O2
- 分子量:312.37
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Calu-3 | CC50 |
>500 μM
Compound: Propamidine
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Cytotoxicity against human Calu-3 cells assessed as reduction in cell viability
Cytotoxicity against human Calu-3 cells assessed as reduction in cell viability
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[PMID: 37284689] |
| HCT-116 | GI50 |
11 μM
Compound: 2 (Propamidine)
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Tested for in vitro concentration required to inhibit growth by 50% against HCT116 human colon cancer cell line
Tested for in vitro concentration required to inhibit growth by 50% against HCT116 human colon cancer cell line
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[PMID: 11755363] |
| HT-29 | GI50 |
>50 μM
Compound: 2 (Propamidine)
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Tested for in vitro concentration required to inhibit growth by 50% against HT-29 human colon cancer cell line
Tested for in vitro concentration required to inhibit growth by 50% against HT-29 human colon cancer cell line
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[PMID: 11755363] |
| MCF7 | GI50 |
9 μM
Compound: 2 (Propamidine)
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Tested for in vitro concentration required to inhibit growth by 50% against MCF-7 human breast cancer cell line cell line
Tested for in vitro concentration required to inhibit growth by 50% against MCF-7 human breast cancer cell line cell line
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[PMID: 11755363] |
| NCI/ADR-RES | GI50 |
33 μM
Compound: 2 (Propamidine)
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Tested for in vitro concentration required to inhibit growth by 50% against MCF-7/ADR human breast cancer cell line cell line
Tested for in vitro concentration required to inhibit growth by 50% against MCF-7/ADR human breast cancer cell line cell line
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[PMID: 11755363] |
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 104-32-5
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性状 Solid
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分子量 312.37
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分子式 C17H20N4O2
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Color White to off-white
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SMILES
N=C(C1=CC=C(C=C1)OCCCOC(C=C2)=CC=C2C(N)=N)N
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 8.33 mg/mL (26.67 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (264 KB)
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SDS (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.2013 mL | 16.0067 mL | 32.0133 mL | 80.0333 mL |
| 5 mM | 0.6403 mL | 3.2013 mL | 6.4027 mL | 16.0067 mL | |
| 10 mM | 0.3201 mL | 1.6007 mL | 3.2013 mL | 8.0033 mL | |
| 15 mM | 0.2134 mL | 1.0671 mL | 2.1342 mL | 5.3356 mL | |
| 20 mM | 0.1601 mL | 0.8003 mL | 1.6007 mL | 4.0017 mL | |
| 25 mM | 0.1281 mL | 0.6403 mL | 1.2805 mL | 3.2013 mL |
Propamidine 関連分類
HY-130402B 関連分類
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