PVZB1194
Based on 1 Customer Validation
PVZB1194 is a biphenyl-type inhibitor of Kinesin-5 ATPase activity that binds to the α4/α6 site of the motor domain in a nucleotide competitive manner. PVZB1194 has an IC50 of 0.12 μM for KSP ATPase. PVZB1194 induces mitotic arrest with the formation of a monopolar spindle, and inhibits HeLa cells proliferatio (IC50: 5.5 μM). PVZB1194 can be used in the study of tumors.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.64%
- CAS 番号: 1141768-04-8
- 分子式: C13H9F4NO2S
- 分子量:319.27
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Kinesin アイソフォーム固有の製品をすべて表示
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生物活性
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Eg5 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
5.5 μM
Compound: 16, PVZB1194
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Cytotoxicity against human HeLa cells after 48 hrs by MTS assay
Cytotoxicity against human HeLa cells after 48 hrs by MTS assay
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[PMID: 19167222] |
PVZB1194 (1-5 nM; 24-72 h) inhibits cell proliferation and induces mitotic arrest in a concentration-dependent manner in HeLa cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 1141768-04-8
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性状 Solid
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分子量 319.27
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分子式 C13H9F4NO2S
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Color White to off-white
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SMILES
O=S(C1=CC=C(C2=CC=C(C(F)(F)F)C(F)=C2)C=C1)(N)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 250 mg/mL (783.04 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (272 KB)
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- Deutsch - DE (252 KB)
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- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Sawada JI, et al. Various effects of two types of kinesin-5 inhibitors on mitosis and cell proliferation. Biochem Pharmacol. 2021 Nov;193:114789. [Content Brief]
[2]. Matsuno K, et al. Bis(hetero)aryl derivatives as unique kinesin spindle protein inhibitors. Bioorg Med Chem Lett. 2009 Feb 15;19(4):1058-61. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.1321 mL | 15.6607 mL | 31.3215 mL | 78.3036 mL |
| 5 mM | 0.6264 mL | 3.1321 mL | 6.2643 mL | 15.6607 mL | |
| 10 mM | 0.3132 mL | 1.5661 mL | 3.1321 mL | 7.8304 mL | |
| 15 mM | 0.2088 mL | 1.0440 mL | 2.0881 mL | 5.2202 mL | |
| 20 mM | 0.1566 mL | 0.7830 mL | 1.5661 mL | 3.9152 mL | |
| 25 mM | 0.1253 mL | 0.6264 mL | 1.2529 mL | 3.1321 mL | |
| 30 mM | 0.1044 mL | 0.5220 mL | 1.0440 mL | 2.6101 mL | |
| 40 mM | 0.0783 mL | 0.3915 mL | 0.7830 mL | 1.9576 mL | |
| 50 mM | 0.0626 mL | 0.3132 mL | 0.6264 mL | 1.5661 mL | |
| 60 mM | 0.0522 mL | 0.2610 mL | 0.5220 mL | 1.3051 mL | |
| 80 mM | 0.0392 mL | 0.1958 mL | 0.3915 mL | 0.9788 mL | |
| 100 mM | 0.0313 mL | 0.1566 mL | 0.3132 mL | 0.7830 mL |
PVZB1194 関連分類
HY-122247 関連分類
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