PROTAC RIPK2 Degrader-1
RIPK2-IN-2 (example 25) is a RIP2 kinase PROTAC inhibitor. RIPK2-IN-2 can block RIP2-dependent proinflammatory signaling, regulated RIP2 kinase activity in auto inflammatory diseases.
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- CAS 番号: 2143956-20-9
- 分子式: C53H65FN14O7S2
- 分子量:1093.30
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
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RIPK2 |
RIPK2-IN-2 (example 25) can simultaneously bind RIP2 kinase and an E3 ubiquitin ligase (VHL), which promotes ubiquitination of RIP2 Kinase and leads to RIP2 kinase degradation by the proteasome. through proteolysis targeting chimeric molecules PROTACs technology, RIPK2-IN-2 (example 25) can promotes ubiquitination of RIP2 Kinaseand degrade RIP2 kinase with the concentrations of RIPK2-IN-2﹤1 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:THP1 cells
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Concentration:﹤1 μM
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Incubation Time:12 h
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Result:Displayed > 80% degradation of RIP2 at concentrations ﹤1 μM.
化学情報
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CAS 番号 2143956-20-9
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分子量 1093.30
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分子式 C53H65FN14O7S2
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SMILES
O=C(N1CCC(CC1)[C@H](NC([C@H](C)NC)=O)C(N2[C@@](C3=NC(C(C4=CC=C(C=C4)F)=O)=CS3)([H])CCC2)=O)C5=CN=C(N=C5)N(CC6)CCN6CCOC(C(S(C(C)(C)C)(=O)=O)=C7)=CC8=C7C(NC9=NNC(C)=C9C)=NC=N8
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
PROTAC RIPK2 Degrader-1 関連分類
HY-147235 関連分類
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