SCH-202676
Based on 1 Customer Validation
SCH-202676 is an allosteric modulator of G protein-coupled receptors (GPCRs) and adenosine receptor (AR). SCH-202676 has antiviral activity and inhibits 3CLpro in a time-dependent manner with an IC50 value of 0.655 µM.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.46%
- CAS 番号: 70375-43-8
- 分子式: C15H13N3S
- 分子量:267.35
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Adenosine Receptor アイソフォーム固有の製品をすべて表示
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生物活性
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Adenosine A3 receptor |
SCH-202676 (compound 6a) (0.01-10 µM; 0, 5, 10 and 20 min) shows antiviral activity and inhibits 3CLpro in a time-dependent manner, with IC50 values of 0.409, 0.302, 0.206 and 0.191 µM for 0, 5, 10 and 20 min, respectively[1].
SCH-202676 (10 μM; 90 min) enhances the labelling of [35S]GTPγS in rat forebrain membranes[2].
SCH-202676 inhibits the agonist [3H]UK-14,304 (HY-B0659) and the antagonist [3H] Yohimbine (HY-12715) binding to the α2a adrenergic receptor[3].
SCH-202676 (10 μM) selectively accelerates agonist dissociation at adenosine A3 receptors, slows antagonist dissociation at adenosine Ai receptors, accelerates antagonist dissociation at adenosine AzA receptors[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 70375-43-8
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性状 Solid
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分子量 267.35
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分子式 C15H13N3S
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Color Off-white to light yellow
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SMILES
C/N=C1N=C(C2=CC=CC=C2)N(C3=CC=CC=C3)S/1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 100 mg/mL (374.04 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (280 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Ren P, et al. Discovery, synthesis and mechanism study of 2,3,5-substituted [1,2,4]-thiadiazoles as covalent inhibitors targeting 3C-Like protease of SARS-CoV-2. Eur J Med Chem. 2023 Jan 18;249:115129. [Content Brief]
[2]. Lewandowicz AM, et al. The 'allosteric modulator' SCH-202676 disrupts G protein-coupled receptor function via sulphydryl-sensitive mechanisms. Br J Pharmacol. 2006 Feb;147(4):422-9. [Content Brief]
[4]. Gao ZG, et al. Effects of the allosteric modulator SCH-202676 on adenosine and P2Y receptors. Life Sci. 2004 May 7;74(25):3173-80. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.7404 mL | 18.7021 mL | 37.4042 mL | 93.5104 mL |
| 5 mM | 0.7481 mL | 3.7404 mL | 7.4808 mL | 18.7021 mL | |
| 10 mM | 0.3740 mL | 1.8702 mL | 3.7404 mL | 9.3510 mL | |
| 15 mM | 0.2494 mL | 1.2468 mL | 2.4936 mL | 6.2340 mL | |
| 20 mM | 0.1870 mL | 0.9351 mL | 1.8702 mL | 4.6755 mL | |
| 25 mM | 0.1496 mL | 0.7481 mL | 1.4962 mL | 3.7404 mL | |
| 30 mM | 0.1247 mL | 0.6234 mL | 1.2468 mL | 3.1170 mL | |
| 40 mM | 0.0935 mL | 0.4676 mL | 0.9351 mL | 2.3378 mL | |
| 50 mM | 0.0748 mL | 0.3740 mL | 0.7481 mL | 1.8702 mL | |
| 60 mM | 0.0623 mL | 0.3117 mL | 0.6234 mL | 1.5585 mL | |
| 80 mM | 0.0468 mL | 0.2338 mL | 0.4676 mL | 1.1689 mL | |
| 100 mM | 0.0374 mL | 0.1870 mL | 0.3740 mL | 0.9351 mL |
SCH-202676 関連分類
HY-133862 関連分類
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