SHR-1806

SHR-1806 (0.1-10000 ng/mL) binds specifically and potently to human and rhesus monkey OX40 in an ELISA format, with comparable EC₅₀ values of 61.47 ng/mL and 60.80 ng/mL, respectively^[1].
SHR-1806 (0.0001-100 nM; 1 h) exhibits potent, specific binding to OX40-expressing CHOK1-hOX40 cells and activated human T cells, with EC₅₀ values of 1.99 nM and 0.20 nM, respectively, and no binding to activated mouse or rat T cells^[1].
SHR-1806 (0.01-100 nM; 1 h) potently blocks the interaction between OX40 and OX40L in CHOK1-hOX40L cells, with an IC₅₀ of 12.51 nM^[1].
SHR-1806 (0.01-100 nM; 5 h) potently activates NF-κB signaling in Jurkat-NF-κB-Luc-hOX40 cells co-cultured with Raji cells, with an EC₅₀ of 0.36 nM, demonstrating greater potency than GPX4^[1].
SHR-1806 (1-1000 ng/mL; 72 h) potently activates human memory CD4⁺ T cells to secrete IFN-γ, with greater activity than the reference antibody GPX4 at equivalent concentrations^[1].
SHR-1806 (0.01-100 nM; 15 min) exhibits potent ADCC activity against HEK293-hOX40 cells, with an EC₅₀ of 0.01 nM, demonstrating superior potency compared to GPX4^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.