Sphingolactone-24
Sphingolactone-24 (Sph-24) is a selective and irreversible neutral sphingomyelinase (nSMase) inhibitor. Sphingolactone-24 has the potential for the research of acute lung injury.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 881177-99-7
- 分子式: C18H29NO4
- 分子量:323.43
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Phospholipase アイソフォーム固有の製品をすべて表示
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生物活性
Sphingolactone-24 (50 µM; 30 min+24 h) inhibits LPS-induced p38 MAPK phosphorylation and antagonized the antiapoptotic effect LPS (HY-D1056)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human neutrophils
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Concentration:50 µM
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Incubation Time:30 min +24 h (30 min before LPS (500 ng/ml) treatment)
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Result:Inhibited LPS-induced p38 MAPK phosphorylation and antagonized the antiapoptotic effect of LPS.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C3H/HeN breeder mice (LPS 10 mg/kg; intranasal instillation)[1]
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Dosage:1 mg/kg
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Administration:I.p.; 3 and 9 h thereafter LPS
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Result:Improved survival and reduced the severity of LPS-induced acute lung injury (ALI).
化学情報
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CAS 番号 881177-99-7
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分子量 323.43
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分子式 C18H29NO4
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SMILES
C/C=C/C=C/C(N[C@H]([C@@]1([H])CC(C(O1)=O)CCCCCC)CO)=O
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別名
Sph-24
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Sphingolactone-24 関連分類
HY-136994 関連分類
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