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United States

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製品番号: HY-155070

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SRE-II

SRE-II, an amide derivative, is an activatable photosensitizer for photodynamic cancer research with decreased fluorescence and photosensitizing capabilities. SRE-II can be further converted into the active photosensitizer SDU Red via carboxylesterase-catalyzed amide bond cleavage. SRE-II induces DNA damage and cell apoptosis in the presence of light. SRE-II can act as a promising theranostic agent for triple-negative breast cancer.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₁₅H₉ClINO₂
分子量:397.59

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

SRE-II 構造式

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

DNA/RNA Synthesis アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
4T1	IC₅₀	1.31 μM Compound: SRE-II	Anticancer activity against mouse 4T1 cells assessed as reduction in cell viability preincubated for 2 hrs followed by photoirradiation with 500 to 700nm and 12 J/cm^2 LED light for 24 hrs by CCK-8 assay Anticancer activity against mouse 4T1 cells assessed as reduction in cell viability preincubated for 2 hrs followed by photoirradiation with 500 to 700nm and 12 J/cm^2 LED light for 24 hrs by CCK-8 assay	[PMID: 37119664]
MDA-MB-231	IC₅₀	1.59 μM Compound: SRE-II	Anticancer activity against human MDA-MB-231 cells assessed as reduction in cell viability preincubated for 2 hrs followed by photoirradiation with 500 to 700nm and 12 J/cm^2 LED light for 24 hrs by CCK-8 assay Anticancer activity against human MDA-MB-231 cells assessed as reduction in cell viability preincubated for 2 hrs followed by photoirradiation with 500 to 700nm and 12 J/cm^2 LED light for 24 hrs by CCK-8 assay	[PMID: 37119664]

化学情報

分子量 397.59
分子式 C₁₅H₉ClINO₂
SMILES

O=C(C=C1)C2=CC=CC3=C(NC(CCl)=O)C(I)=CC1=C32
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (269 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Qiaoyun Jiang, et al. Lysosome-targeting phenalenones as efficient type I/II photosensitizers for anticancer photodynamic therapy. Eur J Med Chem. 2023 Jul 5;255:115418. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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