SU0383
SU0383 is a dual MTH1 and OGG1 inhibitor with IC50 values of 0.034 μM and 0.49 μM, respectively. SU0383 induces cytotoxicity in cancer cells and increases sensitivity of tumor cells to oxidative stress, and showing low toxicity in normal cells. SU0383 can be used for cancer research.
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- CAS 番号: 2598151-90-5
- 分子式: C33H34N6O5S
- 分子量:626.73
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
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MTH1 0.034 μM (IC50) |
OGG1 0.49 μM (IC50) |
SU0383 (5-20 µM; 24-72 h) induces cytotoxicity at 20 μM in A549, H460, and HCT116 cells[1].
SU0383 (0.01-10 μM; 24 h) shows low toxicity in MCF-7 and HeLa cells[2].
SU0383 (10 μM; 16 h) increases the sensitivity of MCF-7 tumor cells to oxidative stress induced by hydrogen peroxide[2].
SU0383 (10 μM) engages native NUDT1 in MCF7 cells and inhibits native OGG1 activity in MCF7 lysate[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A549, H460, HCT116
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Concentration:5-20 μM
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Incubation Time:24, 48, 72 h
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Result:Induced noticeable cytotoxicity only at 20 μM in A549, H460, and HCT116 cells.
Showed no significant cytotoxicity at lower concentrations.
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Cell Line:MCF-7 and HeLa human cell lines
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Concentration:0.01, 0.1, 1, 10 μM
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Incubation Time:24 h
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Result:Displayed little or no measurable toxicity in MCF-7 and HeLa cells at concentrations up to 10 μM.
化学情報
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CAS 番号 2598151-90-5
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分子量 626.73
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分子式 C33H34N6O5S
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SMILES
O=C(NCCOC1=NC(=NC=C1C)N)C=2C=CC=C(C2)C=3C=CC(=CC3)S(=O)(=O)NC4=CC=C5C(=C4)N(C(=O)C6CC6)CCC5
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
SU0383 関連分類
HY-180404 関連分類
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