Tec-IN-14
Tec-IN-14 blocks the interaction between Tec kinase and FGF2 with an IC50 of 7.0 μM. Tec-IN-14 inhibits the non-classical secretion of FGF2 in cells. Tec-IN-14 suppresses the tyrosine phosphorylation of FGF2 in a cellular environment. Tec-IN-14 is applicable to research related to cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 852838-07-4
- 分子式: C18H16BrN3O4
- 分子量:418.25
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Tec-IN-14 (compound 14) (50 μM) inhibits tyrosine phosphorylation of FGF2 in FGF2-GFP-expressing CHO cells[1].
Tec-IN-14 (10-50 μM; 40 h) inhibits the non-canonical secretion of FGF2 in CHO cells in a dose-dependent manner[1].
Tec-IN-14 (10-50 μM; 72 h) exerts no significant pleiotropic effects on the viability or proliferation of CHO cells, but only causes a slight reduction in proliferation rate[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:CHO cells with Doxycycline (HY-N0565)-inducible FGF2-GFP expression
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Concentration:10, 25, and 50 μM
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Incubation Time:40 h (including 24 h pre-incubation and 16 h doxycycline-induced expression)
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Result:Inhibited FGF2-GFP secretion to cell surfaces in a dose-dependent manner.
化学情報
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CAS 番号 852838-07-4
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分子量 418.25
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分子式 C18H16BrN3O4
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SMILES
O=C(OCC=1N=C2C=CC(Br)=CN2C(=O)C1)C=3NC(=C(C(=O)C)C3C)C
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Tec-IN-14 関連分類
HY-111289 関連分類
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