Thymohydroquinone
Based on 1 Customer Validation
Thymohydroquinone is a COX-2 inhibitor and anti-SARS-CoV-2 agent that induces cytotoxicity, antiproliferative effects and inhibits tumor growth. Thymohydroquinone cannot scavenge superoxide radicals via σ (hydrogen atom transfer) and π-π attacks with superoxide anions. Thymohydroquinone can be used in research related to squamous cell carcinoma, fibrosarcoma and coronavirus disease 2019 (SARS-CoV-2 infection).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.91%
- CAS 番号: 2217-60-9
- 分子式: C10H14O2
- 分子量:166.22
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保管条件:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
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COX-2 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A2780 | IC50 |
3.1 μM
Compound: 18
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Growth inhibition of human A2780 cells after 72 hrs by SRB assay
Growth inhibition of human A2780 cells after 72 hrs by SRB assay
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[PMID: 29519737] |
| A2780cis | IC50 |
9.8 μM
Compound: 18
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Growth inhibition of human A2780cis cells after 72 hrs by SRB assay
Growth inhibition of human A2780cis cells after 72 hrs by SRB assay
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[PMID: 29519737] |
| OVCAR-8 | IC50 |
8.9 μM
Compound: 18
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Growth inhibition of human OVCAR8 cells after 72 hrs by SRB assay
Growth inhibition of human OVCAR8 cells after 72 hrs by SRB assay
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[PMID: 29519737] |
Thymohydroquinone (0.01-0.1 mg/mL; 24 h) exhibits dose-dependent, statistically significant cytotoxic activity against L929 mouse fibroblast cells, SCC VII mouse squamous cell carcinoma cells, and FsaR mouse fibrosarcoma cells[1].
Thymohydroquinone inhibits SARS-CoV-2 in VERO-E6 cells with an IC50 of 23.15 ng/mL[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:L929 mouse fibroblasts, SCC VII mouse squamous cell carcinoma cells, FsaR mouse fibrosarcoma cells
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Concentration:0.01-0.1 mg/mL
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Incubation Time:24 h
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Result:Induced 21% cell growth inhibition in L929 cells, 17% cell growth inhibition in SCC VII cells, and 15% cell growth inhibition in FsaR cells at 0.01 mg/mL.
Induced 63% cell growth inhibition in L929 cells, 87% cell growth inhibition in SCC VII cells, and 92% cell growth inhibition in FsaR cells at 0.1 mg/mL.
Showed statistically significant (p < 0.01) dose-dependent cytotoxic activity, with greater inhibition against tumor cell lines (SCC VII, FsaR) than against normal L929 fibroblasts at the 0.1 mg/mL concentration.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C3HHf/BuZgr/Hr (male, 3 months old; fibrosarcoma or squamous cell carcinoma cell subcutaneous transplantation)[1]
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Dosage:5 mg/kg per injection; total cumulative dose of 20 mg/kg
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Administration:intratumoral; on days 3, 4, 5, 11 post-tumor cell inoculation
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Result:Achieved a tumor growth inhibition (TGI) of up to 49% against SCC VII tumors and up to 33% against FsaR tumors.
Showed statistically significant differences in tumor growth compared with control mice (p < 0.05) at multiple time points post-inoculation.
Exhibited no statistically significant difference in in vivo antitumor activity compared with thymoquinone.
化学情報
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CAS 番号 2217-60-9
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性状 Solid
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分子量 166.22
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分子式 C10H14O2
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Color White to off-white
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SMILES
OC1=CC(C(C)C)=C(O)C=C1C
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
H2O : 1 mg/mL (6.02 mM; ultrasonic and warming and heat to 60°C)
DMSO : 1 mg/mL (6.02 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (276 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Ivankovic S, et al. The antitumor activity of thymoquinone and thymohydroquinone in vitro and in vivo. Exp Oncol. 2006;28(3):220-224. [Content Brief]
[2]. Esharkawy ER, et al. In vitro potential antiviral SARS-CoV-19- activity of natural product thymohydroquinone and dithymoquinone from Nigella sativa. Bioorg Chem. 2022;120:105587. [Content Brief]
[3]. Sakib R, et al. Antioxidant Properties of Thymoquinone, Thymohydroquinone and Black Cumin (Nigella sativa L.) Seed Oil: Scavenging of Superoxide Radical Studied Using Cyclic Voltammetry, DFT and Single Crystal X-ray Diffraction. Antioxidants (Basel). 2023;12(3):607. Published 2023 Mar 1. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 6.0161 mL | 30.0806 mL | 60.1612 mL | 150.4031 mL |
| 5 mM | 1.2032 mL | 6.0161 mL | 12.0322 mL | 30.0806 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Thymohydroquinone 関連分類
HY-W196368 関連分類
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