Tilivapram
Based on 1 Customer Validation
Tilivapram (AVE8112) is an orally active PDE4 inhibitor with procognitive effects. Tilivapram exhibits in vivo efficacy and improves processing speed and psychomotor speed. Oral administration of tilivapram may induce dose-related adverse reactions such as nausea and dizziness, but transdermal delivery enables slow, controlled elevation of plasma concentrations, thereby significantly reducing gastrointestinal discomfort and dizziness. Tilivapram is applicable to research related to neuropsychiatric disorders.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.96%
- CAS 番号: 166741-91-9
- 分子式: C16H15Cl2N3O4
- 分子量:384.21
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
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PDE4 |
Tilivapram has a wide therapeutic window within the dose range of 0.5 mg to 1.5 mg. Tilivapram modulates electroencephalogram features (such as reducing resting-state θ power, enhancing θ coherence and γ phase-locking during stimulus processing) and mismatch negativity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 166741-91-9
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性状 Solid
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分子量 384.21
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分子式 C16H15Cl2N3O4
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Color Off-white to light yellow
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SMILES
ClC1=C(NC(C2=NC=C(OC)C(OCC3CC3)=C2)=O)C(Cl)=C[N+]([O-])=C1
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別名
AVE8112
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 50 mg/mL (130.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (271 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6027 mL | 13.0137 mL | 26.0274 mL | 65.0686 mL |
| 5 mM | 0.5205 mL | 2.6027 mL | 5.2055 mL | 13.0137 mL | |
| 10 mM | 0.2603 mL | 1.3014 mL | 2.6027 mL | 6.5069 mL | |
| 15 mM | 0.1735 mL | 0.8676 mL | 1.7352 mL | 4.3379 mL | |
| 20 mM | 0.1301 mL | 0.6507 mL | 1.3014 mL | 3.2534 mL | |
| 25 mM | 0.1041 mL | 0.5205 mL | 1.0411 mL | 2.6027 mL | |
| 30 mM | 0.0868 mL | 0.4338 mL | 0.8676 mL | 2.1690 mL | |
| 40 mM | 0.0651 mL | 0.3253 mL | 0.6507 mL | 1.6267 mL | |
| 50 mM | 0.0521 mL | 0.2603 mL | 0.5205 mL | 1.3014 mL | |
| 60 mM | 0.0434 mL | 0.2169 mL | 0.4338 mL | 1.0845 mL | |
| 80 mM | 0.0325 mL | 0.1627 mL | 0.3253 mL | 0.8134 mL | |
| 100 mM | 0.0260 mL | 0.1301 mL | 0.2603 mL | 0.6507 mL |
Tilivapram 関連分類
HY-14826 関連分類
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