UU-T03
UU-T03 is a β-catenin/Tcf protein-protein interaction inhibitor and an inhibitor of Wnt signaling activation. UU-T03 downregulates the expression of AXIN2, LGR5, cyclin D1, and c-myc. UU-T03 inhibits the growth of colorectal cancer cells. UU-T03 can be used for research on colorectal cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1586007-00-2
- 分子式: C37H41ClN4O9
- 分子量:721.20
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
製品説明
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| SW480 | IC50 |
28.73 μM
|
Inhibition of Wnt-responsive luciferase activity in human SW480 colorectal cancer cells transfected with TOPFlash reporter.
Inhibition of Wnt-responsive luciferase activity in human SW480 colorectal cancer cells transfected with TOPFlash reporter.
|
24191653 |
| HEK293 | IC50 |
37.57 μM
|
Inhibition of Wnt-responsive luciferase activity in Wnt-activated human HEK293 cells co-transfected with β-catenin and TOPFlash reporter.
Inhibition of Wnt-responsive luciferase activity in Wnt-activated human HEK293 cells co-transfected with β-catenin and TOPFlash reporter.
|
24191653 |
| SW480 | IC50 |
10.77 μM
|
Antiproliferative activity against human SW480 colorectal cancer cells assessed as growth inhibition by MTs assay.
Antiproliferative activity against human SW480 colorectal cancer cells assessed as growth inhibition by MTs assay.
|
24191653 |
| HT-29 | IC50 |
11.01 μM
|
Antiproliferative activity against human HT29 colorectal cancer cells assessed as growth inhibition by MTs assay.
Antiproliferative activity against human HT29 colorectal cancer cells assessed as growth inhibition by MTs assay.
|
24191653 |
| HCT-116 | IC50 |
28.83 μM
|
Antiproliferative activity against human HCT116 colorectal cancer cells assessed as growth inhibition by MTs assay.
Antiproliferative activity against human HCT116 colorectal cancer cells assessed as growth inhibition by MTs assay.
|
24191653 |
| HEK293 | IC50 |
84.02 μM
|
Cytotoxicity against normal human HEK293 cells assessed as cell viability reduction by MTs assay.
Cytotoxicity against normal human HEK293 cells assessed as cell viability reduction by MTs assay.
|
24191653 |
体外実験
UU-T03 downregulates AXIN2, LGR5, cyclin D1, and c-myc mRNA in SW480 cells in a dose-dependent manner[1].
UU-T03 (7.5-60 µM) reduced cyclin D1 and c-myc protein levels in SW480 cells without affecting β-catenin protein[1].
UU-T03 (0-60 µM) selectively disrupts β-catenin/Tcf interactions in HCT116 cells in a dose-dependent manner, without affecting β-catenin/cadherin and β-catenin/APC interactions[1].
UU-T03 inhibited the growth of SW480, HT29, and HCT116 colorectal cancer cells with IC50 values of 10.77, 11.01, and 28.83 µM, respectively, and exhibited an IC50 of 84.02 µM in normal HEK293 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
-
CAS 番号 1586007-00-2
-
分子量 721.20
-
分子式 C37H41ClN4O9
-
SMILES
C(C(N[C@@H](CC1=CC2=C(C=C1)C=CC=C2)C(N[C@H](C(N[C@@H](CCC(OCC)=O)C(OC)=O)=O)CC(OCC)=O)=O)=O)C=3NC=4C(C3)=CC(Cl)=CC4
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Huang Z, et al. Targeting the Tcf4 G13ANDE17 binding site to selectively disrupt β-catenin/T-cell factor protein-protein interactions. ACS chemical biology. 2014 Jan 17;9(1):193-201. [Content Brief]
[2]. Pećina-Šlaus N, et al. Wnt Signaling Inhibitors and Their Promising Role in Tumor Treatment. International journal of molecular sciences. 2023 Apr 04;24(7):6733. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
UU-T03 関連分類
HY-122679 関連分類
Powered by Bioz