製品番号: HY-N1098

Velutin

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Velutin is a flavonoid. Velutin can be extracted from mistletoe. Velutin inhibits mushroom Tyrosinase activity with an IC₅₀ of 910.1 μM. Velutin inhibits p38 phosphorylation, the NF-κB pathway and the MAPK pathway. Velutin prevents articular cartilage degeneration and subchondral bone loss. Velutin slows down the progression of intervertebral disc degeneration. Velutin exhibits inhibitory effects on melanogenesis, skin whitening, anti-inflammatory, anti-allergic, anti-oxidant and antibacterial activities. Velutin can be used in studies related to pigmented diseases, osteoarthritis and intervertebral disc degeneration.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度: 98.60%
CAS 番号: 25739-41-7
分子式: C₁₇H₁₄O₆
分子量:314.29

保管条件:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Velutin 構造式

CAS 番号: 25739-41-7

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- Cellular Effect
- 体外実験
- 体内実験
化学情報
溶剤 & 溶解度
- 体外
純度とドキュメンテーション
参考文献
Help & FAQs
Bioz

生物活性

製品説明

p38 MAPK アイソフォーム固有の製品をすべて表示 :

NF-κB アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	IC₅₀	>20 μg/mL Compound: 4',5-dihydroxy-3',7-dimethoxyflavone	Cytotoxicity against human A2780 cells Cytotoxicity against human A2780 cells	[PMID: 15217279]
KB	IC₅₀	1.5 μg/mL Compound: Velutin	Cytotoxicity against human KB cells after 72 hrs by neutral red assay Cytotoxicity against human KB cells after 72 hrs by neutral red assay	[PMID: 10075750]
KB	IC₅₀	1.5 μg/mL Compound: 4, Velutin	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 8759170]
Neutrophil	IC₅₀	<=12.51 μM Compound: 59	Inhibition of fMLF/CB-induced human Neutrophil activation assessed as reduction in superoxide anion generation pre-incubated for 2 mins prior to CB induction for 3 mins followed by fMLF addition by spectrophotometric analysis Inhibition of fMLF/CB-induced human Neutrophil activation assessed as reduction in superoxide anion generation pre-incubated for 2 mins prior to CB induction for 3 mins followed by fMLF addition by spectrophotometric analysis	[PMID: 37683361]
Neutrophil	IC₅₀	<=15.25 μM Compound: 59	Inhibition of fMLF/CB-induced human Neutrophil activation assessed as reduction in elastase release using MeO-Suc-Ala-Ala-Pro-Val-pnitroanilide as substrate pre-incubated for 2 mins followed by fMLF/CB-stimulation and measured for 5 mins Inhibition of fMLF/CB-induced human Neutrophil activation assessed as reduction in elastase release using MeO-Suc-Ala-Ala-Pro-Val-pnitroanilide as substrate pre-incubated for 2 mins followed by fMLF/CB-stimulation and measured for 5 mins	[PMID: 37683361]
P388	IC₅₀	10 μg/mL Compound: 4, Velutin	Cytotoxicity against mouse P388 cells Cytotoxicity against mouse P388 cells	[PMID: 8759170]

体外実験

Velutin (2-200 μM; 10 min) potently scavenges ABTS free radicals in cell-free assays, with an EC₅₀ value of 23.13 μM^[1].
Velutin (0.01-1 mM; pre-incubated with tyrosinase for 30 min, followed by incubation with L-tyrosine for 10 min) inhibits mushroom tyrosinase activity in cell-free assays, with an IC₅₀ of 910.1 μM^[1].
Velutin (10 μM; 48 h) completely inhibits α-MSH-induced melanogenesis in B16F10 mouse melanoma cells^[1].
At a concentration of 10 μM with 48 h incubation, velutin inhibits α-MSH-induced intracellular tyrosinase activity by 87% in B16F10 mouse melanoma cells^[1].
Velutin (0-32 μM; 24-48 h) exhibits no cytotoxicity toward primary mouse chondrocytes, with the maximum concentration reaching 32 μM after 24 h or 48 h of incubation^[2].
Velutin (32 μM; 7 days) protects primary mouse chondrocytes against IL-1β-induced inflammation and extracellular matrix degradation after 7 days of incubation^[2].
Velutin (4 μM; 2 h) inhibits RANKL-induced activation of p38 MAPK in mouse bone marrow-derived macrophages^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

B16F10 murine melanoma cells
Concentration:

20 μM
Incubation Time:

24 h
Result:

Showed no significant cytotoxicity, with cell viability remaining near 100% at 20 μM.

体内実験

Velutin (32 μM; intra-articular injection; once weekly for 8 consecutive weeks) exerts dual protective effects against articular cartilage degeneration and subchondral bone loss in DMM-induced osteoarthritis mice, reduces the OARSI score, increases the expression of aggrecan and type Ⅱ collagen, and inhibits the activation of p-p38 MAPK^[2].
Velutin (i.p.; once daily; for 4 consecutive weeks; 5-10 mg/kg) dose-dependently alleviates intervertebral disc degeneration in a mouse model of lumbar instability^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6 (7-week-old male, DMM-induced osteoarthritis)^[2]
Dosage:

32 μM
Administration:

intra-articular injection; once weekly; 8 weeks
Result:

Showed significantly more regular articular cartilage surfaces, a thicker AC layer, a thinner calcified cartilage layer, and a lower osteophyte score.
Increased AC thickness, reduced CC thickness, and increased the AC/CC ratio.
Increased subchondral bone thickness, and significantly reduced the number of TRAP (+) multinucleated osteoclasts in SCB.
Increased aggrecan and type II collagen expression.
Reduced AC destruction and deeper Safranin O staining, with lower Osteoarthritis Research Society International scores.
Increased trabecular bone volume/tissue volume and trabecular number, and reduced trabecular separation in SCB, reducing SCB loss.
Significantly reduced p-p38 MAPK expression.

化学情報

CAS 番号 25739-41-7
性状 Solid
分子量 314.29
分子式 C₁₇H₁₄O₆
Color White to yellow
SMILES

O=C1C=C(C2=CC=C(O)C(OC)=C2)OC3=CC(OC)=CC(O)=C13
Structure Classification
- Flavonoids
- Flavones
- Phenols
- Polyphenols
Initial Source
- Plants
- other families
- Microorganisms
Flammulina velutipes
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶剤 & 溶解度

体外:

DMSO : 50 mg/mL (159.09 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.1818 mL

15.9089 mL

31.8177 mL

5 mM

0.6364 mL

3.1818 mL

6.3635 mL

10 mM

0.3182 mL

1.5909 mL

3.1818 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (277 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Jung SH, et al. Anti-Melanogenic Properties of Velutin and Its Analogs. Molecules. 2021;26(10):3033. Published 2021 May 19. [Content Brief]

[2]. Wang K, et al. Dual protective role of velutin against articular cartilage degeneration and subchondral bone loss via the p38 signaling pathway in murine osteoarthritis. Front Endocrinol (Lausanne). 2022;13:926934. Published 2022 Jul 22. [Content Brief]

[3]. Zhang Y, et al. Velutin Inhibits IL-1β-Induced Nucleus Pulposus Inflammatory and Extracellular Matrix Degradation Attenuating Mouse Intervertebral Disc Degeneration via the NF-κB and MAPK Pathways. Mediators Inflamm. 2025 Nov 20;2025:9625485. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.1818 mL	15.9089 mL	31.8177 mL	79.5444 mL
	5 mM	0.6364 mL	3.1818 mL	6.3635 mL	15.9089 mL
	10 mM	0.3182 mL	1.5909 mL	3.1818 mL	7.9544 mL
	15 mM	0.2121 mL	1.0606 mL	2.1212 mL	5.3030 mL
	20 mM	0.1591 mL	0.7954 mL	1.5909 mL	3.9772 mL
	25 mM	0.1273 mL	0.6364 mL	1.2727 mL	3.1818 mL
	30 mM	0.1061 mL	0.5303 mL	1.0606 mL	2.6515 mL
	40 mM	0.0795 mL	0.3977 mL	0.7954 mL	1.9886 mL
	50 mM	0.0636 mL	0.3182 mL	0.6364 mL	1.5909 mL
	60 mM	0.0530 mL	0.2651 mL	0.5303 mL	1.3257 mL
	80 mM	0.0398 mL	0.1989 mL	0.3977 mL	0.9943 mL
	100 mM	0.0318 mL	0.1591 mL	0.3182 mL	0.7954 mL

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Velutin

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p38 MAPK アイソフォーム固有の製品をすべて表示

NF-κB アイソフォーム固有の製品をすべて表示

生物活性

化学情報

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

Velutin 関連分類

製品番号: HY-N1098