Viscosalactone B
Viscosalactone B is a withanolide found in Withania somnifera. Viscosalactone B shows potent inhibitory activities to NCI-H460, HCT-116, MCF-7 and SF-268 cancer cells with IC50 values of 0.32, 0.47, 0.4 and 0.45 μg/mL. Viscosalactone B can be used for the research of cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 76938-46-0
- 分子式: C28H40O7
- 分子量:488.61
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
生物活性
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
>40 μM
Compound: 43
|
Cytotoxicity against human A549 cells assessed as reduction in cell viability using compound addition to cell culture cells in lag phase of growth and incubated for 48 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability using compound addition to cell culture cells in lag phase of growth and incubated for 48 hrs by MTT assay
|
[PMID: 28923386] |
| A549 | IC50 |
>40 μM
Compound: 43
|
Cytotoxicity against human A549 cells assessed as reduction in cell viability using compound addition to cell culture cells in log phase of growth and incubated for 48 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability using compound addition to cell culture cells in log phase of growth and incubated for 48 hrs by MTT assay
|
[PMID: 28923386] |
| B16-F10 | IC50 |
>10 μM
Compound: 18
|
Cytotoxicity against mouse B16F10 cells after 72 hrs by MTS assay
Cytotoxicity against mouse B16F10 cells after 72 hrs by MTS assay
|
[PMID: 22098611] |
| HeLa | IC50 |
>40 μM
Compound: 43
|
Cytotoxicity against human HeLa cells assessed as reduction in cell viability using compound addition to cell culture cells in lag phase of growth and incubated for 48 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as reduction in cell viability using compound addition to cell culture cells in lag phase of growth and incubated for 48 hrs by MTT assay
|
[PMID: 28923386] |
| HeLa | IC50 |
>40 μM
Compound: 43
|
Cytotoxicity against human HeLa cells assessed as reduction in cell viability using compound addition to cell culture cells in log phase of growth and incubated for 48 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as reduction in cell viability using compound addition to cell culture cells in log phase of growth and incubated for 48 hrs by MTT assay
|
[PMID: 28923386] |
| MCF7 | IC50 |
>40 μM
Compound: 43
|
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability using compound addition to cell culture cells in lag phase of growth and incubated for 48 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability using compound addition to cell culture cells in lag phase of growth and incubated for 48 hrs by MTT assay
|
[PMID: 28923386] |
| MCF7 | IC50 |
>40 μM
Compound: 43
|
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability using compound addition to cell culture cells in log phase of growth and incubated for 48 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability using compound addition to cell culture cells in log phase of growth and incubated for 48 hrs by MTT assay
|
[PMID: 28923386] |
| NCI-H929 | IC50 |
>10 μM
Compound: 3
|
Cytotoxicity against human NCI-H929 cells after 3 days by Alamar blue assay
Cytotoxicity against human NCI-H929 cells after 3 days by Alamar blue assay
|
[PMID: 24625088] |
| SK-MEL-28 | IC50 |
>10 μM
Compound: 18
|
Cytotoxicity against human SK-MEL-28 cells after 72 hrs by MTS assay
Cytotoxicity against human SK-MEL-28 cells after 72 hrs by MTS assay
|
[PMID: 22098611] |
| Vero | IC50 |
>40 μM
Compound: 43
|
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability using compound addition to cell culture cells in lag phase of growth and incubated for 48 hrs by MTT assay
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability using compound addition to cell culture cells in lag phase of growth and incubated for 48 hrs by MTT assay
|
[PMID: 28923386] |
| Vero | IC50 |
>40 μM
Compound: 43
|
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability using compound addition to cell culture cells in log phase of growth and incubated for 48 hrs by MTT assay
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability using compound addition to cell culture cells in log phase of growth and incubated for 48 hrs by MTT assay
|
[PMID: 28923386] |
化学情報
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CAS 番号 76938-46-0
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分子量 488.61
-
分子式 C28H40O7
-
SMILES
C[C@]12[C@@]3([C@H]([C@H](CC2=O)O)O)[C@](C[C@]4([H])[C@]1([H])CC[C@]5([C@@]4([H])CC[C@]5([H])[C@@H]([C@@]6([H])CC(C)=C(C(O6)=O)CO)C)C)([H])O3
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)