Wistin
Based on 1 Customer Validation
Wistin, isolated from Caragana sinica roots, is a PPARα and PPARγ agonist.
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- 純度: 97.63%
- CAS 番号: 19046-26-5
- 分子式: C23H24O10
- 分子量:460.43
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保管条件:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Wistin, is a PPARγ agonist that can induce the mRNA expression of the PPARγ target gene adiponectin in mouse 3T3-L1 cells[2].
Wistin inhibits cellular triglyceride accumulation in hepatocytes (P<0.05 at 10 μg/mL) in a dose-dependent manner[2].
Wistin (10 μg/mL) results in a 2.5-, 7.2-, and 14.8-fold increase in the expression levels of CPT1a, ACO, and ACS, respectively[2].
Treatment with Wistin for 48 h significantly decreases the amount of cellular TG in mouse primary hepatocytes in a dose-dependent manner[2].
Treatment with wistin enhanced the marker of adipocyte differentiation, such as triglyceride accumulation in 3T3-L1 cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Mouse hepatocytes.
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Concentration:1 or 10 μg/mL.
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Incubation Time:48 h.
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Result:Significantly increased PPARα mRNA levels in a dose-dependent manner.
化学情報
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CAS 番号 19046-26-5
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性状 Solid
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分子量 460.43
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分子式 C23H24O10
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Color White to off-white
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SMILES
O=C1C2=CC(OC)=C(O[C@@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)CO)C=C2OC=C1C4=CC=C(C=C4)OC
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
純度とドキュメンテーション
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データシート (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. SeonJu Park, et al. Neuraminidase Inhibitors from the Roots of Caragana sinica. Chem Biodivers. 2020 Nov;17(11):e2000470. [Content Brief]
[2]. Misato Suzuki, et al. 4',6-Dimethoxyisoflavone-7-O-β-D-glucopyranoside (wistin) is a peroxisome proliferator-activated receptor α (PPARα) agonist in mouse hepatocytes. Mol Cell Biochem. 2018 Sep;446(1-2):35-41. [Content Brief]
[3]. Matoki Sanada, et al. 4',6-dimethoxyisoflavone-7-O-β-D-glucopyranoside (wistin) is a peroxisome proliferator-activated receptor γ (PPARγ) agonist that stimulates adipocyte differentiation. Anim Sci J. 2016 Nov;87(11):1347-1351. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Wistin 関連分類
HY-N9333 関連分類
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