WWQ-131
WWQ-131 is a potent selective JAK2 inhibitor with an IC50 of 2.56 nM. WWQ-131 shows >252-fold selectivity over JAK1, JAK3, and TYK2. WWQ-131 exhibits antiproliferative activity against cancer cells. WWQ-131 is the ligand for target protein for PROTAC JAK2 degrader-1 (HY-174428). WWQ-131 can be used for the research of myeloproliferative neoplasms (MPNs).
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1558007-80-9
- 分子式: C21H23ClFN5O
- 分子量:415.89
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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JAK2 2.56 nM (IC50) |
JAK1 647.35 nM (IC50) |
JAK3 528.61 nM (IC50) |
Tyk2 1298.13 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| NIH3T3 | IC50 |
387 nM
Compound: 1a
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Inhibition of human EML4-fused ALK L1196M mutant expressed in mouse NIH-3T3 cells assessed as phospho-ALK level after 1 hr by sandwich ELISA
Inhibition of human EML4-fused ALK L1196M mutant expressed in mouse NIH-3T3 cells assessed as phospho-ALK level after 1 hr by sandwich ELISA
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[PMID: 24432909] |
WWQ-131 inhibits the proliferation of SET-2 and HEL cells with IC50 values of 1.15 and 2.36 μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 1558007-80-9
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分子量 415.89
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分子式 C21H23ClFN5O
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SMILES
FC1=CC([C@H](OC2=C(N=CC(C3=CN(N=C3)C4CCNCC4)=C2)N)C)=C(C=C1)Cl
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
WWQ-131 関連分類
HY-174430 関連分類
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