Cat. No.: HY-N0272

Eleutheroside E

2 Cited Publications

Customer Review

Based on 2 publication(s) in Google Scholar

Eleutheroside E is an important component of ginseng that can be taken orally. Eleutheroside E has anti-inflammatory and antioxidant properties, and it helps reduce apoptosis in heart cells caused by hypoxia-reoxygenation (H/R) damage. Eleutheroside E can improve type 2 diabetes, enhance cognitive function, and has neuroprotective effects.

For research use only. We do not sell to patients.

Purity: 99.60%
CAS No.: 39432-56-9
Formula: C₃₄H₄₆O₁₈
Molecular Weight:742.72

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

Eleutheroside E Chemical Structure

CAS No.: 39432-56-9

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Publications (2)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Bioz

Biological Activity

Description

All NF-κB Isoforms :

In Vitro

Eleutheroside E (10 μM, 24 h) increases insulin-induced glucose uptake in C2C12 myotubes and improves the inhibition of glucose uptake by TNF-α in 3T3-L1 adipocytes^[1].
Eleutheroside E (0-100 μM, 3 h) enhances cell viability in H9c2 cells subjected to H/R injury^[2].
Eleutheroside E (0-100 μM, 12 h) has a protective effect against apoptosis in H9c2 cells induced by H/R injury^[2].
Eleutheroside E (100 μM, 12 h) boosts antioxidant capacity in H9c2 cells^[2].
Eleutheroside E (100 μM, 12 h) blocks the MAPK pathway and inhibits the activation of NF-κB^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:

H9c2, H9c2 (H/r)
Concentration:

0, 30, 60, 100 μM
Incubation Time:

3 h
Result:

Enhanced the cell viability of H9c2 (H/r) cells in a dose-dependent manner and had no effect on normal cells.

Western Blot Analysis^[2]

Cell Line:

H9c2 (H/r)
Concentration:

100 μM
Incubation Time:

12 h
Result:

Reduced the expression of Bax, caspase-3 and caspase-9, and enhanced the expression of Bcl-2. Reduced the expression of Cyt-Cyto-C, reduced the levels of LDH and HMGB1 induced by H₂O₂, and inhibited the phosphorylation of ERK, JNK and p38.

In Vivo

Eleutheroside E (0.003%, oral, daily, for five weeks) improves liver glucose metabolism in obese type 2 diabetes mice by upregulating glycolysis and downregulating gluconeogenesis^[1].
Eleutheroside E (15-60 mg/kg, oral, once daily, three weeks) alleviates arthritis in a collagen-induced arthritis mouse model^[3].
Eleutheroside E (50 mg/kg, oral, once daily, four weeks) prevents cognitive deficits caused by radiation in mice^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

db/db mice^[1]
Dosage:

Containing 0.003% of the diet; 5 weeks
Administration:

Oral
Result:

Improved blood lipids, significantly reduced blood sugar and serum insulin levels, induced HOMA-IR, increased insulin sensitivity, and protected pancreatic α and β cells from diabetic damage.

Animal Model:

Collageninduced arthritis (CIA) mice^[3]
Dosage:

15, 30, 60 mg/kg; daily; 3 weeks
Administration:

Oral
Result:

Reduced mean arthritis score and arthritis incidence, reduced inflammatory cell infiltration, mesenchymal formation, cartilage damage and bone erosion in CIA mice, and decreased TNF-α and IL-6.

Animal Model:

Mice irradiated with 60Co-γ rays^[4]
Dosage:

50 mg/kg; daily; 4 weeks
Administration:

Oral
Result:

Improved cognitive and spatial memory impairments in irradiated mice, protected hippocampal neurons, and activated the PKA/CREB/BDNF signaling pathway.

Chemical Information

CAS No. 39432-56-9
Appearance Solid
Molecular Weight 742.72
Formula C₃₄H₄₆O₁₈
Color White to off-white
SMILES

COC(C=C1[C@H]2[C@@](CO[C@@H]3C4=CC(OC)=C(O[C@@H]([C@@H]([C@@H](O)[C@@H]5O)O)O[C@@H]5CO)C(OC)=C4)([H])[C@]3([H])CO2)=C(C(OC)=C1)O[C@@H]([C@@H]([C@@H](O)[C@@H]6O)O)O[C@@H]6CO
Structure Classification
- Phenylpropanoids
- Lignans
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (2)

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Journal Impact Factor

Acupunct Herb Med

2025 February 25.
J Pharm Pharmacol

Eleutheroside E functions as anti-cervical cancer drug by inhibiting the phosphatidylinositol 3-kinase pathway and reprogramming the metabolic responses. [Abstract]

2022 Sep 1;74(9):1251-1260. PMID: 35789274

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (134.64 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 1 mg/mL (1.35 mM; Need ultrasonic)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.3464 mL

6.7320 mL

13.4640 mL

5 mM

0.2693 mL

1.3464 mL

2.6928 mL

10 mM

0.1346 mL

0.6732 mL

1.3464 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass

Concentration

Volume

Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (3.37 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (3.37 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (3.37 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage
mg/kg
Animal Weight (Per Animal)
g
Dosing Volume (Per Animal)
μL
Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (285 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chunyan He, et al. Eleutheroside E Ameliorates Arthritis Severity in Collagen-Induced Arthritis Mice Model by Suppressing Inflammatory Cytokine Release. Inflammation, Vol. 37, No. 5, October 2014 (# 2014)

[2]. Jiyun Ahn, et al. Eleutheroside E, An Active Component of Eleutherococcus senticosus, Ameliorates Insulin Resistance in Type 2 Diabetic db/db Mice. Evid Based Complement Alternat Med. 2013; 2013: 934183.

[3]. Wang S, et al. Eleutheroside E decreases oxidative stress and NF-κB activation and reprograms the metabolic response against hypoxia-reoxygenation injury in H9c2 cells. Int Immunopharmacol. 2020 Jul;84:106513. [Content Brief]

[4]. Chen Song, et al. Eleutheroside E supplementation prevents radiation-induced cognitive impairment and activates PKA signaling via gut microbiota. Commun Biol. 2022 Jul 8;5(1):680. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O / DMSO	1 mM	1.3464 mL	6.7320 mL	13.4640 mL	33.6601 mL
DMSO	5 mM	0.2693 mL	1.3464 mL	2.6928 mL	6.7320 mL
	10 mM	0.1346 mL	0.6732 mL	1.3464 mL	3.3660 mL
	15 mM	0.0898 mL	0.4488 mL	0.8976 mL	2.2440 mL
	20 mM	0.0673 mL	0.3366 mL	0.6732 mL	1.6830 mL
	25 mM	0.0539 mL	0.2693 mL	0.5386 mL	1.3464 mL
	30 mM	0.0449 mL	0.2244 mL	0.4488 mL	1.1220 mL
	40 mM	0.0337 mL	0.1683 mL	0.3366 mL	0.8415 mL
	50 mM	0.0269 mL	0.1346 mL	0.2693 mL	0.6732 mL
	60 mM	0.0224 mL	0.1122 mL	0.2244 mL	0.5610 mL
	80 mM	0.0168 mL	0.0842 mL	0.1683 mL	0.4208 mL
	100 mM	0.0135 mL	0.0673 mL	0.1346 mL	0.3366 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

Eleutheroside E

2 Cited Publications

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Eleutheroside E

Apoptosis Compound Library

Immunology/Inflammation Compound Library

NF-κB Signaling Compound Library

Stem Cell Signaling Compound Library

Natural Product Library

Anti-Cancer Compound Library

Anti-Aging Compound Library

Antioxidant Compound Library

Differentiation Inducing Compound Library

Anti-diabetic Compound Library

Glycoside Compound Library

Oxygen Sensing Compound Library

Medicine Food Homology Compound Library

Glycolysis Compound Library

Pyroptosis Compound Library

Orally Active Compound Library

Traditional Chinese Medicine Active Compound Library

Neuroprotective Compound Library

Anti-Breast Cancer Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Blood Cancer Compound Library

Anti-Cancer Metabolism Compound Library

Anti-Obesity Compound Library

Transcription Factor-Targeted Library

Anti-Liver Cancer Compound Library

Anti-Cancer Natural Product Library

Antidepressant Compound Library

Anti-inflammatory Traditional Chinese Medicine Active Compound Library

Plant-Sourced Natural Product Library

Anti-Prostate Cancer Compound Library

Cancer Stem Cells Compound Library

Pain-Related Compound Library

Cell Death Library

Anti-Hematopathy Compound Library

Anti-Ovarian Cancer Compound Library

Radioprotector Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

Anti-Fibrosis Compound Library

Miao Ethnicity Medicine Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Diarrhea-Related Traditional Chinese Medicine Active Compound Library

Natural Product Diversity Scaffold Library

Tonifying Traditional Chinese Medicine Monomer Compound Library

Lactylation Compound Library

Mass Spectrometry Natural Product Library

Publications Citing Use of MedChemExpress (MCE) Eleutheroside E

All NF-κB Isoforms

Biological Activity

Chemical Information

Publications (2)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Eleutheroside E Related Classifications

Cat. No.: HY-N0272