KB SRC 4
Based on 1 Customer Validation
KB SRC 4 is a potent, and highly selective c-Src inhibitor, with a Ki of 44 nM and a Kd of 86 nM, and shows no inhibition on c-Abl up to 125 μM; KB SRC 4 has antitumor activity.
For research use only. We do not sell to patients.
- Purity : 99.22%
- CAS No.: 1380088-03-8
- Formula: C32H23ClN8
- Molecular Weight:555.03
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
IC50 & Target
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HMEC | GI50 |
4.3 μM
Compound: 1
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Cytotoxicity against human HMEC after 72 hrs by WST1 assay
Cytotoxicity against human HMEC after 72 hrs by WST1 assay
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[PMID: 24015327] |
| SK-BR-3 | GI50 |
4.8 μM
Compound: 1
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Cytotoxicity against human SK-BR-3 cells after 72 hrs by WST1 assay
Cytotoxicity against human SK-BR-3 cells after 72 hrs by WST1 assay
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[PMID: 24015327] |
In Vitro
KB SRC 4 (Compound 4) is a potent, highly selective c-Src inhibitor, with a Ki of 44 nM and a Kd of 86 nM, and shows no inhibition on c-Abl up to 125 μM. KB SRC 4 is selective between Src family members, with >2-fold selectivity over both Lck (Kd, 160 nM) and Fgr (Kd, 240 nM), 8-fold selectivity over c-Yes (Kd, 720 nM), and >40-fold selectivity over Lyn (Kd, 3200 nM), Hck (Kd, 4400 nM), and Fyn (Kd, >40000 nM). KB SRC 4 inhibits the growth of cancer cell lines, with GI50s of 11 μM, 12 μM, 11 μM, 6.0 μM against HT-29, SK-BR-3, MCF7, MDA-MB-453, and NIH-3T3, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1380088-03-8
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Appearance Solid
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Molecular Weight 555.03
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Formula C32H23ClN8
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Color Light brown to brown
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SMILES
NC1=C2C(N(C3=CC=CC(C4=CN=NN4CC5=CC(C6=CC=CC=C6)=CC=C5)=C3)N=C2C7=CC=C(Cl)C=C7)=NC=N1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (180.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8017 mL | 9.0085 mL | 18.0170 mL | 45.0426 mL |
| 5 mM | 0.3603 mL | 1.8017 mL | 3.6034 mL | 9.0085 mL | |
| 10 mM | 0.1802 mL | 0.9009 mL | 1.8017 mL | 4.5043 mL | |
| 15 mM | 0.1201 mL | 0.6006 mL | 1.2011 mL | 3.0028 mL | |
| 20 mM | 0.0901 mL | 0.4504 mL | 0.9009 mL | 2.2521 mL | |
| 25 mM | 0.0721 mL | 0.3603 mL | 0.7207 mL | 1.8017 mL | |
| 30 mM | 0.0601 mL | 0.3003 mL | 0.6006 mL | 1.5014 mL | |
| 40 mM | 0.0450 mL | 0.2252 mL | 0.4504 mL | 1.1261 mL | |
| 50 mM | 0.0360 mL | 0.1802 mL | 0.3603 mL | 0.9009 mL | |
| 60 mM | 0.0300 mL | 0.1501 mL | 0.3003 mL | 0.7507 mL | |
| 80 mM | 0.0225 mL | 0.1126 mL | 0.2252 mL | 0.5630 mL | |
| 100 mM | 0.0180 mL | 0.0901 mL | 0.1802 mL | 0.4504 mL |
KB SRC 4 Related Classifications
HY-108488 Related Classifications
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