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Others Stem Cell/Wnt MAPK/ERK Pathway JAK/STAT Signaling Metabolic Enzyme/Protease TGF-beta/Smad NF-κB Protein Tyrosine Kinase/RTK Epigenetics Immunology/Inflammation Apoptosis Neuronal Signaling GPCR/G Protein
Reference Standards ERK STAT Phosphodiesterase (PDE) PKA p38 MAPK Keap1-Nrf2 JAK Interleukin Related Apoptosis Cannabinoid Receptor
Linderane (Standard)

Cat. No.: HY-N0688R

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Linderane (Standard)

Linderane (Standard) is the analytical standard of Linderane (HY-N0688). This product is intended for research and analytical applications. Linderane is an orally active natural sesquiterpene lactone with blood-brain barrier permeability. Linderane indirectly activates PDE3 by activating ERK/STAT3, thereby inhibiting the cAMP/PKA/CREB signaling pathway and hepatic gluconeogenesis. Linderane protects pancreatic β cells against oxidative damage by inhibiting the activation of the p38 MAPK pathway and activating the Nrf2 pathway. Linderane inhibits cell apoptosis and ameliorates intestinal mucosal inflammation by suppressing the IL-6/JAK/STAT3 signaling pathway. Linderane reduces pain sensitivity and alleviates anxiety-like behaviors by activating cannabinoid receptor 2 (CB2R). Linderane can be used in studies related to type 2 diabetes, ulcerative colitis, and chronic inflammatory pain with anxiety.

For research use only. We do not sell to patients.

CAS No.: 13476-25-0
Formula: C₁₅H₁₆O₄
Molecular Weight:260.29

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Linderane (Standard) Chemical Structure

CAS No.: 13476-25-0

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Chemical Information
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Product Information

Information

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 13476-25-0
Molecular Weight 260.29
Formula C₁₅H₁₆O₄
SMILES

O=C(O[C@@]1([H])C2=C3OC=C2C)C4(CC/C=C(C)\C3)[C@@H]1O4
Structure Classification
- Terpenoids
- Sesquiterpenes
Initial Source
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

References

[1]. Xie W, et al. Linderane Suppresses Hepatic Gluconeogenesis by Inhibiting the cAMP/PKA/CREB Pathway Through Indirect Activation of PDE 3 via ERK/STAT3. Frontiers in pharmacology. 2018;9:476. [Content Brief]

[2]. Zhang H, et al. Linderane protects pancreatic β cells from streptozotocin (STZ)-induced oxidative damage. Life sciences. 2019 Sep 15;233:116732. [Content Brief]

[3]. Lai H, et al. Linderane from Lindera aggregata attenuates ulcerative colitis by suppressing IL-6/STAT3-mediated Th17 differentiation and apoptosis resistance. Journal of ethnopharmacology. 2026 Feb 28;357:120965. [Content Brief]

[4]. Chen Y, et al. Linderane Attenuates Complete Freund's Adjuvant-Induced Pain and Anxiety in Mice by Restoring Anterior Cingulate Cortex Microglia M2 Polarization through Activating Cannabinoid 2 Receptor. ACS pharmacology & translational science. 2024 Mar 08;7(3):797-808. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

100 mg

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