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Precemtabart

(Synonyms: MBE-748; M-9140 Antibody; MBE-2882 Antibody)
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Based on 1 Customer Validation

Precemtabart is a humanized IgG1 antibody targeting CEACAM5, with selectivity for CEACAM5-positive cells. Precemtabart binds to CEACAM5 on tumor cells to deliver the topoisomerase 1 inhibitor Exatecan (HY-13631), and induces cell death by inhibiting the function of TOP1. Precemtabart inhibits the growth of CEACAM5-positive cancer cells. Precemtabart causes dose-dependent hematolymphoid and intestinal-related effects in cynomolgus monkeys. Precemtabart can be used in research related to metastatic colorectal cancer, metastatic pancreatic ductal carcinoma, advanced gastric cancer, advanced non-small cell lung cancer, and advanced pancreatic adenocarcinoma.

For research use only. We do not sell to patients.

  • Purity: 99.00%
  • CAS No.: 2883118-92-9
  • Molecular Weight:144.471 kDa
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Precemtabart
  • Experimental Validation Results for Precemtabart
  • Experimental Validation Results for Precemtabart
  • Precemtabart Chemical Structure
    Precemtabart Chemical Structure
CAS No.: 2883118-92-9
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Precemtabart Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Top Publications Citing

Use of MCE Products

All Topoisomerase Isoforms

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Assay Types
  • 1/16

    IgG1-kappa

  • 1/16

    Loaded Precemtabart on AHC2 biosensor, can bind CEACAM5 Protein, Human (HEK293, His, HY-P70675) with an affinity constant of 3.214E-09 M as determined in BLI assay.

  • 1/16

    Flow cytometric analysis of 1X106 MCF-7 cells with Precemtabart (HY-P990940, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Precemtabart Chemical Structure
    1/16
  • Precemtabart
  • Loaded Precemtabart on AHC2 biosensor, can bind CEACAM5 Protein, Human (HEK293, His, HY-P70675) with an affinity constant of 3.214E-09 M as determined in BLI assay.
  • Flow cytometric analysis of 1X106 MCF-7 cells with Precemtabart (HY-P990940, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
  • IgG1-kappa