PD-1
Programmed cell death protein 1 (PD-1, CD279) is an inhibitory receptor of the CD28 superfamily induced on activated, exhausted and antigen-experienced T cells, B cells, NK cells and myeloid cells. PD-1 engages two ligands, PD-L1 (B7-H1/CD274), inducibly expressed on hematopoietic and parenchymal cells, and PD-L2 (B7-DC/CD273), restricted to dendritic cells and macrophages. Ligand binding phosphorylates the PD-1 cytoplasmic ITIM and ITSM motifs, recruiting SHP-2 phosphatase that attenuates TCR and CD28 proximal signaling, blunting proliferation, cytokine output, cytotoxicity and survival. This pathway physiologically limits autoimmunity and tissue damage during chronic antigen exposure, but is co-opted by tumors and chronic infections to sustain T-cell exhaustion. PD-1 blockade with pembrolizumab, nivolumab, cemiplimab and related antibodies has revolutionized oncology across dozens of cancer types; PD-1 is also implicated in primary biliary cholangitis and lupus autoimmunity.
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PD-1 Recombinant Proteins (36)
PD-1 Protein, Human (HEK293, His)
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Cat. No.: HY-P7396
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PDCD1; Systemic Lupus Erythematosus Susceptibility 2; Prev. SLEB2; HPD-1; PD1; Programmed Cell Death 1 Protein; Programmed Cell Death Protein 1; CD279 Antigen; CD279; ADMIO4; HSLE1; AIMTBS; PD-1; HPD-L; Programmed Cell Death 1; Protein PD-1
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PD-1 Protein, Human (CHO, Fc)
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Cat. No.: HY-P7395
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PDCD1; Systemic Lupus Erythematosus Susceptibility 2; Prev. SLEB2; HPD-1; PD1; Programmed Cell Death 1 Protein; Programmed Cell Death Protein 1; CD279 Antigen; CD279; ADMIO4; HSLE1; AIMTBS; PD-1; HPD-L; Programmed Cell Death 1; Protein PD-1
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PD-1 Protein, Human (HEK293, mFc)
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Cat. No.: HY-P70525
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PDCD1; Systemic Lupus Erythematosus Susceptibility 2; Prev. SLEB2; HPD-1; PD1; Programmed Cell Death 1 Protein; Programmed Cell Death Protein 1; CD279 Antigen; CD279; ADMIO4; HSLE1; AIMTBS; PD-1; HPD-L; Programmed Cell Death 1; Protein PD-1
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PD-1 Protein, Human (Biotinylated, HEK293, His-Avi)
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Cat. No.: HY-P72406
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PDCD1; Systemic Lupus Erythematosus Susceptibility 2; Prev. SLEB2; HPD-1; PD1; Programmed Cell Death 1 Protein; Programmed Cell Death Protein 1; CD279 Antigen; CD279; ADMIO4; HSLE1; AIMTBS; PD-1; HPD-L; Programmed Cell Death 1; Protein PD-1
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PD-1 Protein, Human (Biotinylated, HEK293, Fc-Avi)
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Cat. No.: HY-P78191
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: PDCD1; Systemic Lupus Erythematosus Susceptibility 2; Prev. SLEB2; HPD-1; PD1; Programmed Cell Death 1 Protein; Programmed Cell Death Protein 1; CD279 Antigen; CD279; ADMIO4; HSLE1; AIMTBS; PD-1; HPD-L; Programmed Cell Death 1; Protein PD-1
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PD-1 Protein, Human (147a.a, HEK293, His)
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Cat. No.: HY-P70766
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PDCD1; Systemic Lupus Erythematosus Susceptibility 2; Prev. SLEB2; HPD-1; PD1; Programmed Cell Death 1 Protein; Programmed Cell Death Protein 1; CD279 Antigen; CD279; ADMIO4; HSLE1; AIMTBS; PD-1; HPD-L; Programmed Cell Death 1; Protein PD-1
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PD-1 Protein, Human (HEK293, hFc)
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Cat. No.: HY-P73344A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.;≥ 90%, as determined by HPLC.
Synonyms: PDCD1; Systemic Lupus Erythematosus Susceptibility 2; Prev. SLEB2; HPD-1; PD1; Programmed Cell Death 1 Protein; Programmed Cell Death Protein 1; CD279 Antigen; CD279; ADMIO4; HSLE1; AIMTBS; PD-1; HPD-L; Programmed Cell Death 1; Protein PD-1
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PD-1 Protein, Human (C93S, HEK293, His)
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Cat. No.: HY-P70799
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PDCD1; Systemic Lupus Erythematosus Susceptibility 2; Prev. SLEB2; HPD-1; PD1; Programmed Cell Death 1 Protein; Programmed Cell Death Protein 1; CD279 Antigen; CD279; ADMIO4; HSLE1; AIMTBS; PD-1; HPD-L; Programmed Cell Death 1; Protein PD-1
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PD-1 Protein, Mouse (HEK293, His-Fc)
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Cat. No.: HY-P73724
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PDCD1; Systemic Lupus Erythematosus Susceptibility 2; Prev. SLEB2; HPD-1; PD1; Programmed Cell Death 1 Protein; Programmed Cell Death Protein 1; CD279 Antigen; CD279; ADMIO4; HSLE1; AIMTBS; PD-1; HPD-L; Programmed Cell Death 1; Protein PD-1
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PD-1 Protein, Human (HEK293, His-Fc)
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Cat. No.: HY-P73345
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PDCD1; Systemic Lupus Erythematosus Susceptibility 2; Prev. SLEB2; HPD-1; PD1; Programmed Cell Death 1 Protein; Programmed Cell Death Protein 1; CD279 Antigen; CD279; ADMIO4; HSLE1; AIMTBS; PD-1; HPD-L; Programmed Cell Death 1; Protein PD-1
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PD-1 Protein, Canine (HEK293, Fc)
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Cat. No.: HY-P73341
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PDCD1; Systemic Lupus Erythematosus Susceptibility 2; Prev. SLEB2; HPD-1; PD1; Programmed Cell Death 1 Protein; Programmed Cell Death Protein 1; CD279 Antigen; CD279; ADMIO4; HSLE1; AIMTBS; PD-1; HPD-L; Programmed Cell Death 1; Protein PD-1
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PD-1 Protein, Human (Biotinylated, HEK293, His)
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Cat. No.: HY-P77509
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PDCD1; Systemic Lupus Erythematosus Susceptibility 2; Prev. SLEB2; HPD-1; PD1; Programmed Cell Death 1 Protein; Programmed Cell Death Protein 1; CD279 Antigen; CD279; ADMIO4; HSLE1; AIMTBS; PD-1; HPD-L; Programmed Cell Death 1; Protein PD-1
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PD-1 Protein, Rat (HEK293, His)
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Cat. No.: HY-P73347
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PDCD1; Systemic Lupus Erythematosus Susceptibility 2; Prev. SLEB2; HPD-1; PD1; Programmed Cell Death 1 Protein; Programmed Cell Death Protein 1; CD279 Antigen; CD279; ADMIO4; HSLE1; AIMTBS; PD-1; HPD-L; Programmed Cell Death 1; Protein PD-1
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PD-1 Protein, Rhesus Macaque (HEK293, His)
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Cat. No.: HY-P73350
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PDCD1; Systemic Lupus Erythematosus Susceptibility 2; Prev. SLEB2; HPD-1; PD1; Programmed Cell Death 1 Protein; Programmed Cell Death Protein 1; CD279 Antigen; CD279; ADMIO4; HSLE1; AIMTBS; PD-1; HPD-L; Programmed Cell Death 1; Protein PD-1
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PD-1 Protein, Mouse (HEK293, His)
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Cat. No.: HY-P70640
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PDCD1; Systemic Lupus Erythematosus Susceptibility 2; Prev. SLEB2; HPD-1; PD1; Programmed Cell Death 1 Protein; Programmed Cell Death Protein 1; CD279 Antigen; CD279; ADMIO4; HSLE1; AIMTBS; PD-1; HPD-L; Programmed Cell Death 1; Protein PD-1
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PD-1 Protein, Mouse (HEK293, Fc)
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Cat. No.: HY-P70639
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PDCD1; Systemic Lupus Erythematosus Susceptibility 2; Prev. SLEB2; HPD-1; PD1; Programmed Cell Death 1 Protein; Programmed Cell Death Protein 1; CD279 Antigen; CD279; ADMIO4; HSLE1; AIMTBS; PD-1; HPD-L; Programmed Cell Death 1; Protein PD-1
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PD-1 Protein, Cynomolgus (HEK293, His)
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Cat. No.: HY-P70676
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PDCD1; Systemic Lupus Erythematosus Susceptibility 2; Prev. SLEB2; HPD-1; PD1; Programmed Cell Death 1 Protein; Programmed Cell Death Protein 1; CD279 Antigen; CD279; ADMIO4; HSLE1; AIMTBS; PD-1; HPD-L; Programmed Cell Death 1; Protein PD-1
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PD-1 Protein, Canine (HEK293, His, solution)
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Cat. No.: HY-P73342
Purity: ≥ 90%, as determined by reducing SDS-PAGE.;≥ 95%, as determined by HPLC.
Synonyms: PDCD1; Systemic Lupus Erythematosus Susceptibility 2; Prev. SLEB2; HPD-1; PD1; Programmed Cell Death 1 Protein; Programmed Cell Death Protein 1; CD279 Antigen; CD279; ADMIO4; HSLE1; AIMTBS; PD-1; HPD-L; Programmed Cell Death 1; Protein PD-1
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PD-1 Protein, Canine (Biotinylated, HEK293, His-Avi)
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Cat. No.: HY-P73727
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PDCD1; Systemic Lupus Erythematosus Susceptibility 2; Prev. SLEB2; HPD-1; PD1; Programmed Cell Death 1 Protein; Programmed Cell Death Protein 1; CD279 Antigen; CD279; ADMIO4; HSLE1; AIMTBS; PD-1; HPD-L; Programmed Cell Death 1; Protein PD-1
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PD-1 Protein, Rabbit (HEK293, His)
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Cat. No.: HY-P78605
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PDCD1; Systemic Lupus Erythematosus Susceptibility 2; Prev. SLEB2; HPD-1; PD1; Programmed Cell Death 1 Protein; Programmed Cell Death Protein 1; CD279 Antigen; CD279; ADMIO4; HSLE1; AIMTBS; PD-1; HPD-L; Programmed Cell Death 1; Protein PD-1
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
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Capetin (28-54), human
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- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
