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Cat. No.: HY-N2062

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10-Nitrocamptothecin

10-Nitrocamptothecin is a topoisomerase I inhibitor with an IC₅₀ of 0.64 μM. 10-Nitrocamptothecin interferes with the formation of cleavable complexes, thereby inhibiting the activity of Topoisomerase I. 10-Nitrocamptothecin is applicable for cancer research.

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CAS No.: 86639-62-5
화학식: C₂₀H₁₅N₃O₆
분자량:393.35

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

10-Nitrocamptothecin Chemical Structure

CAS No.: 86639-62-5

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
- In Vitro
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References
Calculators
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Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

Topoisomerase I

0.64 μM (IC₅₀)

All Topoisomerase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HL-60	IC₅₀	0.64 μM Compound: 5e	Inhibition of Topoisomerase I by cleavage complex formation in human HL-60 cells Inhibition of Topoisomerase I by cleavage complex formation in human HL-60 cells	[PMID: 8410981]

In Vitro

10-Nitrocamptothecin (Compound 5e) (30 min) inhibits purified calf thymus topoisomerase I by forming a cleavable complex, with an IC₅₀ of 0.64 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 86639-62-5
분자량 393.35
화학식 C₂₀H₁₅N₃O₆
SMILES

O=C1N2C(C(C(C2)=CC3=C4)=NC3=CC=C4[N+]([O-])=O)=CC5=C1COC([C@]5(O)CC)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Wall ME, et al. Plant antitumor agents. 30. Synthesis and structure activity of novel camptothecin analogs. J Med Chem. 1993 Sep 3;36(18):2689-700. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
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- IC₅₀ & Target
- In Vitro
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10-Nitrocamptothecin

All Topoisomerase Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

10-Nitrocamptothecin Related Classifications

HY-N2062 Related Classifications