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Cat. No.: HY-108705

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BI-3802

Name: BI-3802
Brand: MedChemExpress
SKU: HY-108705
Price: 148.00 USD
Availability: InStock
Rating: 5 (3 reviews)

3 Cited Publications

고객리뷰

Based on 3 publication(s) in Google Scholar

BI-3802, a chemical probe, is a highly potent BCL6 degrader and inhibits the Bric-à-brac (BTB) domain of BCL6 with an IC₅₀ of ≤3 nM. BI-3802 induces the polymerization of BCL6 and promotes BCL6 degration depended on E3 ligase SIAH1. BI-3802 has antitumor activity.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.

Purity : 99.27%
CAS No.: 2166387-65-9
화학식: C₂₄H₂₉ClN₆O₃
분자량:484.98

보관:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

BI-3802 Chemical Structure

CAS No.: 2166387-65-9

사이즈

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수량

Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (3)
용액&용해도
- In Vitro
Protocol (1)
순도&문서
References
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

IC50: ≤ 3 nM (BCL6 BTB)^[1]

All Bcl-2 Family Isoforms :

In Vitro

BI-3802 shows an IC₅₀ of 43 nM for the cellular BCL6^[1].
BI-3802 increases the interaction between BCL6 and SIAH1 (EC₅₀ = 64 nM)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 2166387-65-9
Appearance Solid
분자량 484.98
화학식 C₂₄H₂₉ClN₆O₃
Color White to off-white
SMILES

ClC1=CN=C(N2C[C@H](C)C[C@H](C)C2)N=C1NC3=CC(C=C(OCC(NC)=O)C(N4C)=O)=C4C=C3
선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (3)

All Bio/Physico-chemical AssayCell Imaging/Staining

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Journal Impact Factor

Nat Commun

Human iPSC-based Modeling of Pulmonary Fibrosis Reveals p300/CBP Inhibition Suppresses Alveolar Transitional Cell State. [Abstract]

2026 Feb 12;17(1):1214. PMID: 41680175
Genome Biol

Imbalanced chromatin distribution in cellular senescence specifies paraspeckle dynamics. [Abstract]

2025 Sep 2;26(1):264. PMID: 40898359

BI-3802 purchased from MedChemExpress. Usage Cited in: Genome Biol. 2025 Sep 2;26(1):264. [Abstract]

Terminal cumulative MSD of NONO-GFP foci at final time point. Each circle indicates a single NONO-GFP focus. For untransfected groups, 45 foci were analyzed from 10 cells; for + BI-3802, 38 from 15 cells; and for + BI-3812, 37 foci from 15 cells across three biological replicates.

BI-3802 purchased from MedChemExpress. Usage Cited in: Genome Biol. 2025 Sep 2;26(1):264. [Abstract]

Compared to cells untransfected with the inducible HP1α switch, both the length of trajectories and terminal MSD of NONO-GFP foci were increased by the promoted condensation of HP1α using BI-3802 (1 μM).
bioRxiv

Rewiring the fusion oncoprotein EWS/FLI1 in Ewing sarcoma with bivalent small molecules. [Abstract]

2025 Mar 17:2025.03.14.643353. PMID: 40166278

용액&용해도

In Vitro:

DMSO : 6.67 mg/mL (13.75 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.0619 mL

10.3097 mL

20.6194 mL

5 mM

0.4124 mL

2.0619 mL

4.1239 mL

10 mM

0.2062 mL

1.0310 mL

2.0619 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Protocol

All Animals and Diseases

Subcutaneous Cell-Line-Derived Xenograft
Subcutaneous cell-line-derived xenograft (CDX) models are established by implanting cultured human cancer cell lines into immunodeficient mice, where the injected cells form localized tumors that can be monitored in vivo as a measure of tumorigenic potential, growth kinetics, and treatment response. These models are widely used in oncology research because they allow reproducible tumor formation and enable comparative assessment of tumor growth between different cell lines or genetic manipulations in a controlled in vivo microenvironment. Subcutaneous implantation of cancer cells in immunodeficient mice is a standard approach for evaluating tumor growth behavior and therapeutic response across multiple cancer types, including prostate, esophageal, pancreatic, and colon cancer models.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kerres N, et al. Chemically Induced Degradation of the Oncogenic Transcription Factor BCL6. Cell Rep. 2017 Sep 19;20(12):2860-2875. [Content Brief]

[2]. Mikołaj Słabicki, et al. Small-molecule-induced polymerization triggers degradation of BCL6. Nature. 2020 Nov 18. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.0619 mL	10.3097 mL	20.6194 mL	51.5485 mL
	5 mM	0.4124 mL	2.0619 mL	4.1239 mL	10.3097 mL
	10 mM	0.2062 mL	1.0310 mL	2.0619 mL	5.1549 mL

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (3)
용액&용해도
- In Vitro
Protocol
순도&문서
References

1/16
1/16

BI-3802 purchased from MedChemExpress. Usage Cited in: Genome Biol. 2025 Sep 2;26(1):264. [Abstract]

Customer Validation
Terminal cumulative MSD of NONO-GFP foci at final time point. Each circle indicates a single NONO-GFP focus. For untransfected groups, 45 foci were analyzed from 10 cells; for + BI-3802, 38 from 15 cells; and for + BI-3812, 37 foci from 15 cells across three biological replicates.
1/16

BI-3802 purchased from MedChemExpress. Usage Cited in: Genome Biol. 2025 Sep 2;26(1):264. [Abstract]

Customer Validation
Compared to cells untransfected with the inducible HP1α switch, both the length of trajectories and terminal MSD of NONO-GFP foci were increased by the promoted condensation of HP1α using BI-3802 (1 μM).

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BI-3802

Publications Citing Use of MedChemExpress (MCE) BI-3802

All Bcl-2 Family Isoforms